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Rajwinder Lehal

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Related publications (14)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

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Related publications (14)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Very High Throughput Electrical Cell Lysis and Extraction of Intracellular Compounds Using 3D Carbon Electrodes in Lab-on-a-Chip Devices

Rodrigo Martinez Duarte, Philippe Renaud, Freddy Radtke, Rajwinder Lehal

Here we present an electrical lysis throughput of 600 microliters per minute at high cell density (108 yeast cells per ml) with 90% efficiency, thus improving the current common throughput of one microliter per minute. We also demonstrate the extraction of ...

2012

Identification and Preclinical Validation of Novel Inhibitors of the Notch Pathway

Rajwinder Lehal

Notch signaling is among one of the highly conserved developmental pathways. Because of its role in the regulation of stem cell self-renewal and cell fate decisions, Notch signaling maintains tissue homeostasis in several organs such as thymus, skin and in ...

EPFL2011

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Ute Koch, Nadine Fournier, Rajwinder Lehal, Linlin Cao, Michele Vigolo, Jelena Zaric

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020