Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Home

Person

Eilif Benjamin Muller

This person has left EPFL

About
Privacy
Disclaimer

Graph Chatbot

Related publications (36)

Page 2 of 2

Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons

Henry Markram, Eilif Benjamin Muller, Idan Segev, Giuseppe Chindemi

The NMDA spike is a long-lasting nonlinear phenomenon initiated locally in the dendritic branches of a variety of cortical neurons. It plays a key role in synaptic plasticity and in single-neuron computations. Combining dynamic system theory and computatio ...

2017

From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells

Henry Markram, Eilif Benjamin Muller, Idan Segev, Werner Alfons Hilda Van Geit

In the neocortex, inhibitory interneurons of the same subtype are electrically coupled with each other via dendritic gap junctions (GJs). The impact of multiple GJs on the biophysical properties of interneurons and thus on their input processing is unclear ...

Oxford University Press (OUP)2016

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Thomas Heinis, Werner Alfons Hilda Van Geit, Rodrigo de Campos Perin, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Farhan Tauheed, Julian Charles Shillcock, Pramod Shivaji Kumbhar, Gilad Silberberg, Ying Shi, Vincent Delattre, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Jean-Vincent Le Bé, Julie Meystre, Taylor Howard Newton, Max Christian Nolte, Nicolas Antille, Georges Khazen, Sébastien Lasserre, Jean Pierre Ghobril, Jeffrey Christopher Muller, Aleksandr Ovcharenko, Shruti Muralidhar, Ahmet Bilgili, Daniel Nachbaur

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

The SONATA data format for efficient description of large-scale network models

Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, James Gonzalo King, Jean-Denis Georges Emile Courcol, Judit Planas Carbonell, Michael Emiel Gevaert, Juan Bautista Hernando Vieites, Adrien Michel Achille Devresse

Increasing availability of comprehensive experimental datasets and of high-performance computing resources are driving rapid growth in scale, complexity, and biological realism of computational models in neuroscience. To support construction and simulation ...

2020

Adaptation reduces variability of the neuronal population code

Eilif Benjamin Muller

Sequences of events in noise-driven excitable systems with slow variables often show serial correlations among their intervals of events. Here, we employ a master equation for generalized non-renewal processes to calculate the interval and count statistics ...

2011

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, András Ecker, Pramod Shivaji Kumbhar, Giuseppe Chindemi, Daniela Egas Santander, James Bryden Isbister, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

An algorithm to predict the connectome of neural microcircuits

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King

Experimentally mapping synaptic connections, in terms of the numbers and locations of their synapses and estimating connection probabilities, is still not a tractable task, even for small volumes of tissue. In fact, the six layers of the neocortex contain ...

Frontiers Research Foundation2015

Distinct Activity Profiles of Somatostatin-Expressing Interneurons in the Neocortex

Eilif Benjamin Muller, Srikanth Ramaswamy, Cristina Colangelo

Frontiers Media Sa2017

A null model of the mouse whole-neocortex micro-connectome

Henry Markram, Michael Reimann, Eilif Benjamin Muller, Ying Shi, Huanxiang Lu

In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale c ...

Nature Research2019

Cortical reliability amid noise and chaos

Henry Markram, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Max Christian Nolte

Typical responses of cortical neurons to identical sensory stimuli appear highly variable. It has thus been proposed that the cortex primarily uses a rate code. However, other studies have argued for spike-time coding under certain conditions. The potentia ...

Nature Research2019

NEURON and Python

Eilif Benjamin Muller

The NEURON simulation program now allows Python to be used, alone or in combination with NEURON's traditional Hoc interpreter. Adding Python to NEURON has the immediate benefit of making available a very extensive suite of analysis tools written for engine ...

Frontiers Research Foundation2009

Specific inhibition and disinhibition in the higher-order structure of a cortical connectome

Eilif Benjamin Muller, Michael Reimann, András Ecker, Daniela Egas Santander

Neurons are thought to act as parts of assemblies with strong internal excitatory connectivity. Conversely, inhibition is often reduced to blanket inhibition with no targeting specificity. We analyzed the structure of excitation and inhibition in the MICrO ...

Oxford University Press2024

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

Simplification of spiking neural network models

Wulfram Gerstner, Henry Markram, Eilif Benjamin Muller, James Gonzalo King, Christian Antonio Pozzorini, Csaba Erö, Christian Andreas Rössert, Idan Segev, Willem Anna Mark Wybo

The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron ...

2024

Reconstruction and simulation of neocortical microcircuitry

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

Simplification of neural network models

Wulfram Gerstner, Henry Markram, Idan Segev, Eilif Benjamin Muller, Marc-Oliver Gewaltig, James Gonzalo King, Christian Antonio Pozzorini, Csaba Erö, Christian Andreas Rössert, Willem Anna Mark Wybo

2018