Publications by Georges Khazen

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The brain is the most mysterious and intricate biological structure known to man. It dominates the way we live, think, reason and behave. It is built of billions of neurons that communicate with each other through trillions of connections using electrical ...

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of s ...

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Understanding the intracellular dynamics of brain cells entails performing three-dimensional molecular simulations incorporating ultrastructural models that can capture cellular membrane geometries at nanometer scales. While there is an abundance of neuron ...

Georges Khazen

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Predictive Engineering the Membrane Composition of Neocortical Neurons

General developmental health in the VPA-rat model of autism

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

Reconstruction and Simulation of Neocortical Microcircuitry

Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling