Publications by Yoji Tabata | EPFL Graph Search

Related publications (9)

In vitro modeling of complex microenvironmental regulation of stem cells

Although stem cells hold tremendous potential for clinical applications, their in vitro manipulation remains very challenging. In vivo, stem cells reside in intricate 3D microenvironments, termed niche, in which many local and systemic extrinsic factors ar ...

EPFL2017

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Matthias Lütolf, Nathalie Brandenberg, Nicolas Antoine Vincent Broguiere, Nikolche Gjorevski, Yoji Tabata, Mikhail Nikolaev, Olga Mitrofanova, Devanjali Dutta, Sara Filipa Da Silva Geraldo Alves, Bilge Sen Elçi

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). However, the approaches that are used at present to derive these organoids in three-dimensional matrices(5,6)r ...

NATURE PUBLISHING GROUP2020

Proliferation, Morphology, and Pluripotency of Mouse Induced Pluripotent Stem Cells in Three Different Types of Alginate Beads for Mass Production

Yoji Tabata

Induced pluripotent stem cells (iPSCs) are expected to be an ideal cell source for biomedical applications, but such applications usually require a large number of cells. Suspension culture of iPSC aggregates can offer high cell yields but sometimes result ...

Wiley-Blackwell2014

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Jeffrey Alan Hubbell, Matthias Lütolf, Yoji Tabata

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Development of bioactive hydrogel capsules for the 3D expansion of pluripotent stem cells in bioreactors

Matthias Lütolf, Yoji Tabata

Pluripotent stem cells hold great promise for many pharmaceutical and therapeutic applications. However, the lack of scalable methodologies to expand these cells to clinically relevant numbers is a major roadblock in realizing their full potential. To addr ...

Royal Soc Chemistry2014

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

Ambroise Roger Vuaridel, Matthias Lütolf, Felix Naef, Yoji Tabata, Eric Paquet, François Réal Rivest, Andrea Manfrin

Signaling centers, localized groups of cells that secrete morphogens, play a key role in early development and organogenesis by orchestrating spatial cell fate patterning. Here we present a microfluidic approach that exposes human pluripotent stem cell (hP ...

NATURE PUBLISHING GROUP2019

Defined three-dimensional microenvironments boost induction of pluripotency

Massimiliano Caiazzo, Matthias Lütolf, Alessandra Piersigilli, Adrian Ranga, Yoji Tabata, Yuya Okawa

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

Nature Publishing Group2016

Method and device for mixing two streams of droplets

Matthias Lütolf, Yoji Tabata, Andrea Negro

The invention relates to a method for mixing a first stream of droplets (1) with at least one second stream of droplets (2) to obtain a third stream of fused droplets (3), by collision and fusion of at least one droplet of the first stream (1) with at leas ...

2016

Organoid tissue engineering

Matthias Lütolf, Nathalie Brandenberg, Yoji Tabata, Nikolche Gjorevski, Mikhail Nikolaev, Sara Filipa Da Silva Geraldo Alves

The invention relates to methods for developing and maintaining organoids and the organoids produced thereby. ...

2018