Publications de Yoji Tabata | EPFL Graph Search

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Although stem cells hold tremendous potential for clinical applications, their in vitro manipulation remains very challenging. In vivo, stem cells reside in intricate 3D microenvironments, termed niche, in which many local and systemic extrinsic factors ar ...

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). However, the approaches that are used at present to derive these organoids in three-dimensional matrices(5,6)r ...

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

Pluripotent stem cells hold great promise for many pharmaceutical and therapeutic applications. However, the lack of scalable methodologies to expand these cells to clinically relevant numbers is a major roadblock in realizing their full potential. To addr ...

Signaling centers, localized groups of cells that secrete morphogens, play a key role in early development and organogenesis by orchestrating spatial cell fate patterning. Here we present a microfluidic approach that exposes human pluripotent stem cell (hP ...

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

The invention relates to methods for developing and maintaining organoids and the organoids produced thereby. ...

Yoji Tabata

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In vitro modeling of complex microenvironmental regulation of stem cells

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Development of bioactive hydrogel capsules for the 3D expansion of pluripotent stem cells in bioreactors

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

Defined three-dimensional microenvironments boost induction of pluripotency

Organoid tissue engineering