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Françoise Gisou van der Goot Grunberg

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Related publications (78)

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

Bacterial pathogens modulate host cell apoptosis to establish a successful infection. Pore-forming toxins (PFTs) secreted by pathogenic bacteria are major virulence factors and have been shown to induce various forms of cell death in infected cells. Here w ...

Nature Publishing Group2012

The dark sides of capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julie Deuquet Ariosa

Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 ...

2012

Pathogenic Pore-Forming Proteins: Function and Host Response

Mirko Bischofberger, Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target ...

Cell Press2012

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

Christelle Pythoud, Françoise Gisou van der Goot Grunberg, Stefan Kunz, Marie-Laurence Moraz

The arenavirus Lassa virus (LASV) causes a severe haemorrhagic fever with high mortality in man. The cellular receptor for LASV is dystroglycan (DG). DG is a ubiquitous receptor for extracellular matrix (ECM) proteins, which cooperates with beta 1 integrin ...

Wiley-Blackwell2012

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Nicolas Jean Philippe Guex, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Julie Deuquet Ariosa, Suzanne Salvi

Hyaline Fibromatosis Syndrome (HIS) is a human genetic disease caused by mutations in the anthrax toxin receptor 2 (or cmg2) gene, which encodes a membrane protein thought to be involved in the homeostasis of the extracellular matrix. Little is known about ...

Wiley Open Access2011

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

Françoise Gisou van der Goot Grunberg

Protein export is an essential mechanism in living cells and exported proteins are usually translocated through a protein-conducting channel in an unfolded state. Here we analyze, by electrical detection, the entry and transport of unfolded proteins, at th ...

2011

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Rodrigo Manuel Gonzalez, Bruno Lemaitre, Onya Opota

Pseudomonas entomophila is an entomopathogenic bacterium that infects and kills Drosophila. P. entomophila pathogenicity is linked to its ability to cause irreversible damages to the Drosophila gut, preventing epithelium renewal and repair. Here we report ...

2011

Extending the aerolysin family: from bacteria to vertebrates

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

A number of bacterial virulence factors have been observed to adopt structures similar to that of aerolysin, the principal toxin of Aeromonas species. However, a comprehensive description of architecture and structure of the aerolysin-like superfamily has ...

Public Library of Science2011

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

Matteo Thomas Degiacomi, Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Matteo Dal Peraro, Sylvia Ho

Throughout evolution, one of the most ancient forms of aggression between cells or organisms has been the production of proteins or peptides affecting the permeability of the target cell membrane. This class of virulence factors includes the largest family ...

2011

Pore-forming toxins induce multiple cellular responses promoting survival

Mirko Bischofberger, Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez, Sylvia Ho

Pore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since thi ...

Wiley-Blackwell2011

Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms

Françoise Gisou van der Goot Grunberg

Aerolysin is a major virulence factor produced by the Gram-negative bacterium Aeromonas hydrophila and is a member of the beta-pore-forming toxin family. Two oligomerization-deficient aerolysin mutants, H132D and H132N, have been overproduced, proteolyzed ...

2010

Getting the Opportunity to Fly on your own

Françoise Gisou van der Goot Grunberg

The author describes the beginning of her independent scientific career in the Department of Biochemistry of the University of Geneva, at a time when Assistant Professor positions did not exist there and female group leaders in the Section of Chemistry wer ...

2009

Bacterial pore-forming toxins: the (w)hole story?

Mirko Bischofberger, Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response t ...

Birkhäuser-Verlag, Springer2008

Pore formation: an ancient yet complex form of attack

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

Bacteria, as well as higher organisms such as sea anemones or earthworms, have developed sophisticated virulence factors such as the pore-forming toxins (PFTs) to mount their attack against the host. One of the most fascinating aspects of PFTs is that they ...

2008

Elastic membrane heterogeneity of living cells revealed by stiff nanoscale membrane domains

Charles Roduit, Giovanni Dietler, Paolo De Los Rios, Sandor Kasas, Pascal Steiner, Alexandre Yersin, Françoise Gisou van der Goot Grunberg

Many approaches have been developed to characterize the heterogeneity of membranes in living cells. In this study, the elastic properties of specific membrane domains in living cells are characterized by atomic force microscopy. Our data reveal the existen ...

Elsevier2008

About lipids and toxins

Françoise Gisou van der Goot Grunberg

Many mono or multicellular organisms secrete soluble proteins, referred to as protein toxins, which alter the behavior of foreign, or target cells, possibly leading to their death. These toxins affect either the cell membrane by forming pores or modifying ...

2006

Mechanisms of pathogen entry through the endosomal compartments

Françoise Gisou van der Goot Grunberg

Several pathogens - bacteria, viruses and parasites - must enter mammalian cells for survival, replication and immune-system evasion. These pathogens generally make use of existing cellular pathways that are designed for nutrient uptake, receptor downregul ...

2006

Intra-endosomal membrane traffic

Françoise Gisou van der Goot Grunberg

Following endocytosis, ubiquitinated signaling receptors are incorporated within intraluminal vesicles of forming multivesicular endosomes. These vesicles then follow the pathway from early to late endosomes, remaining within the endosomal lumen, and are e ...

2006

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