Françoise Gisou van der Goot Grunberg

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As concerns regarding sustainability and ethical responsibility in engineering practices continue to rise, it becomes imperative for Higher Education Institutions (HEIs) to equip future engineers with the necessary knowledge and skills to address these cha ...

The invention provides an agent modulating the expression and/or activity of i) the POU5F1B protein, a fragment or variant thereof, ii) an mRNA encoding POU5F1B, a fragment or variant thereof and/or iii) the POU5F1B gene. Preferably, the agent is for use i ...

The present invention relates 1-deoxysphingolipids, as well as pharmaceutically acceptable salts thereof, for use in the prevention and/or treatment of intoxication or viral infections, in particular 1-deoxyceramide or a 1-deoxysphingoid base prodrug there ...

In 1995, in the Biochemical Society Transactions, Mundy published the first review on CLIMP-63 (cytoskeletonlinking membrane protein 63) or CKPA4 (cytoskeleton-associated protein 4), initially just p63 [1]. Here we review the following 20 years of research ...

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. ...

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response t ...

Françoise Gisou van der Goot Grunberg

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INTEGRATING SUSTAINABILITY IN HIGHER EDUCATION INSTITUTIONS: A CASE STUDY FROM EPFL

ANTXR2 as a novel player in skeletal muscle stem cells

Pou5f1b inhibitors

The Molecular Assembly of the Aerolysin Pore Reveals a Unique Swirling Membrane-Insertion Mechanism

Use of deoxysphingolipids as anti-toxins and anti-virals

How many lives does CLIMP-63 have?

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Bacterial pore-forming toxins: the (w)hole story?

Novel mechanistic insights into anthrax toxin endocytosis

Targeting STING with covalent small-molecule inhibitors