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Françoise Gisou van der Goot Grunberg

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Related publications (76)

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Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms

Françoise Gisou van der Goot Grunberg

Aerolysin is a major virulence factor produced by the Gram-negative bacterium Aeromonas hydrophila and is a member of the beta-pore-forming toxin family. Two oligomerization-deficient aerolysin mutants, H132D and H132N, have been overproduced, proteolyzed ...

International Union of Crystallography2010

Biochemical Membrane Lipidomics during Drosophila Development

Françoise Gisou van der Goot Grunberg, Ernst Hafen

Lipids play critical roles in energy homeostasis, membrane structure, and signaling. Using liquid chromatography and mass spectrometry, we provide a comprehensive semiquantification of lipids during the life cycle of Drosophila melanogaster (230 glyceropho ...

Cell Press - Elsevier2013

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

Françoise Gisou van der Goot Grunberg

The arenavirus Lassa virus (LASV) causes a severe haemorrhagic fever with high mortality in man. The cellular receptor for LASV is dystroglycan (DG). DG is a ubiquitous receptor for extracellular matrix (ECM) proteins, which cooperates with beta 1 integrin ...

Wiley-Blackwell2012

Anthrax toxin receptor 2a controls mitotic spindle positioning

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Oriented mitosis is essential during tissue morphogenesis. The Wnt/planar cell polarity (Wnt/PCP) pathway orients mitosis in a number of developmental systems, including dorsal epiblast cell divisions along the animal-vegetal (A-V) axis during zebrafish ga ...

Nature Publishing Group2013

Extending the aerolysin family: from bacteria to vertebrates

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

A number of bacterial virulence factors have been observed to adopt structures similar to that of aerolysin, the principal toxin of Aeromonas species. However, a comprehensive description of architecture and structure of the aerolysin-like superfamily has ...

Public Library of Science2011

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

Françoise Gisou van der Goot Grunberg

Bacterial pathogens modulate host cell apoptosis to establish a successful infection. Pore-forming toxins (PFTs) secreted by pathogenic bacteria are major virulence factors and have been shown to induce various forms of cell death in infected cells. Here w ...

Nature Publishing Group2012

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Nicolas Jean Philippe Guex, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Julie Deuquet Ariosa

Hyaline Fibromatosis Syndrome (HIS) is a human genetic disease caused by mutations in the anthrax toxin receptor 2 (or cmg2) gene, which encodes a membrane protein thought to be involved in the homeostasis of the extracellular matrix. Little is known about ...

Wiley Open Access2011

Dynamics of CLIMP-63 S-acylation control ER morphology

Kathryn Hess Bellwald, Béatrice Kunz, Graham Knott, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Vassily Hatzimanikatis, Patrick Alain Sandoz, Robin Alexander Denhardt-Eriksson, Sylvia Ho, Luciano Andres Abriata, Catherine Maclachlan, Gard Spreemann

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

Nature Portfolio2023

Palmitoylated calnexin is a key component of the ribosome-translocon complex

Thomas Lemmin, Béatrice Kunz, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Matteo Dal Peraro, Sanja Blaskovic

A third of the human genome encodes N-glycosylated proteins. These are co-translationally translocated into the lumen/membrane of the endoplasmic reticulum (ER) where they fold and assemble before they are transported to their final destination. Here, we s ...

2012

Getting the Opportunity to Fly on your own

Françoise Gisou van der Goot Grunberg

The author describes the beginning of her independent scientific career in the Department of Biochemistry of the University of Geneva, at a time when Assistant Professor positions did not exist there and female group leaders in the Section of Chemistry wer ...

2009

Inhibitors of acyl protein thioesterases against microbial infections

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Valeria Cagno, Francisco De Magalhães Sarmento Ribeiro De Mesquita

The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or ba ...

2023

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Françoise Gisou van der Goot Grunberg, Li Jin, Andreas Kern, Maurizio Molinari, Jun Ren, Wei Chen, Jian Zhang, Yi Sun, Ke Liu, Yang Sun, Wei Liu, Peng Wang, Fan Zhang, Jian Wang, Li Zhang, Giuseppe Russo, Hong Zhang, Liang Xu, Jun Li, Jian Yang, Chong Liu, Ke Li

Taylor & Francis Inc2016

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes

Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva

The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two ...

National Academy of Sciences2019

Local and substrate-specific S-palmitoylation determines subcellular localization of G alpha o

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Peripheral membrane proteins (PMPs) associate with cellular membranes through post-translational modifications like S-palmitoylation. The Golgi apparatus is generally viewed as the transitory station where palmitoyl acyltransferases (PATs) modify PMPs, whi ...

Nature Portfolio2022

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

Béatrice Kunz, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Matteo Dal Peraro, Shixu Yan, Luciano Andres Abriata

Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor for both collagen VI and anthrax toxin. Biallelic loss-of-function mutations in CMG2 lead to a severe condition, hyaline fibromatosis syndrome (HFS). We have here dissected a network o ...

Cell Press - Elsevier2020

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

Béatrice Kunz, Didier Trono, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Audrey Geneviève Chuat, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Lucie Josepha Marie Bracq, Nattawadee Panyain

SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observati ...

Nature Research2023

Kicking Out Pathogens in Exosomes

Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva

Host-pathogen interactions involve a series of attacks and counter-attacks. Miao et al. show that, although some invading bacteria can take shelter in lysosomes by neutralizing their pH, this respite is temporary, as host cells can expel them in exosomes. ...

2015

A toxic palmitoylation of Cdc42 enhances NF-kappa B signaling and drives a severe autoinflammatory syndrome

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

MOSBY-ELSEVIER2020

Palmitoylation determines the subcellular localization of the hepatitis E virus ORF3 protein

Françoise Gisou van der Goot Grunberg

ELSEVIER SCIENCE BV2018

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

Béatrice Kunz, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Michal Feldman Elmalam

Many membrane proteins fold inefficiently and require the help of enzymes and chaperones. Here we reveal a novel folding assistance system that operates on membrane proteins from the cytosolic side of the endoplasmic reticulum (ER). We show that folding of ...

Elife Sciences Publications Ltd2016