Publication

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Matteo Dal Peraro, Françoise Gisou van der Goot Grunberg, Florence Pojer, Laurence Gouzi Abrami, Maria Josefina Marcaida Lopez, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Martina Audagnotto, Sylvia Ho, Giulia Fonti, Patrick Alain Sandoz, Muhammad Umair Anwar
2021
Journal Articles

Abstract

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation.

Official source

https://infoscience.epfl.ch/entities/publication/0c2b5e0c-7571-4f53-a2fd-a89af88c33b3

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Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

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