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Publication

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Matteo Dal Peraro, Françoise Gisou van der Goot Grunberg, Florence Pojer, Laurence Gouzi Abrami, Maria Josefina Marcaida Lopez, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Martina Audagnotto, Patrick Alain Sandoz, Sylvia Ho, Giulia Fonti, Muhammad Umair Anwar
2021
Journal Articles

Abstract

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation.

Official source

https://infoscience.epfl.ch/entities/publication/0c2b5e0c-7571-4f53-a2fd-a89af88c33b3

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Abstract

Official source

https://infoscience.epfl.ch/entities/publication/0c2b5e0c-7571-4f53-a2fd-a89af88c33b3

About this result

Ontological neighbourhood

Biology

Cell biology: Membrane biology

Related concepts (28)

Membrane technology

Membrane technology encompasses the scientific processes used in the construction and application of membranes. Membranes are used to facilitate the transport or rejection of substances between mediums, and the mechanical separation of gas and liquid streams. In the simplest case, filtration is achieved when the pores of the membrane are smaller than the diameter of the undesired substance, such as a harmful microorganism.

Lipid bilayer

The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around all cells. The cell membranes of almost all organisms and many viruses are made of a lipid bilayer, as are the nuclear membrane surrounding the cell nucleus, and membranes of the membrane-bound organelles in the cell. The lipid bilayer is the barrier that keeps ions, proteins and other molecules where they are needed and prevents them from diffusing into areas where they should not be.

Post-translational modification

Post-translational modification (PTM) is the covalent process of changing proteins following protein biosynthesis. PTMs may involve enzymes or occur spontaneously. Proteins are created by ribosomes translating mRNA into polypeptide chains, which may then change to form the mature protein product. PTMs are important components in cell signalling, as for example when prohormones are converted to hormones. Post-translational modifications can occur on the amino acid side chains or at the protein's C- or N- termini.

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