Publication

Dynamics of CLIMP-63 S-acylation control ER morphology

Vassily Hatzimanikatis, Françoise Gisou van der Goot Grunberg, Graham Knott, Kathryn Hess Bellwald, Laurence Gouzi Abrami, Catherine Maclachlan, Béatrice Kunz, Sylvia Ho, Gard Spreemann
2023
Journal Articles

Abstract

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediating its oligomerisation, turnover, and localisation.

Official source

https://infoscience.epfl.ch/entities/publication/c742adcc-3c7f-4ce4-8890-b0748149e0c6

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Dynamics of CLIMP-63 S-acylation control ER morphology

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