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Hongxia Lei

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Related publications (68)

Page 2 of 4

Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex

Rolf Gruetter, Hongxia Lei

Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the ...

Wiley-Blackwell2010

The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky. A leaky blood–brain barrier implies high tissue glucose levels and obviates a role for endo ...

Wiley-Blackwell2009

Non-invasive quantification of brain glycogen absolute concentration

Rolf Gruetter, Lijing Xin, Hongxia Lei, Hanne Frenkel, Sabrina Laus, Ruud van Heeswijk

The only currently available method to measure brain glycogen in vivo is C-13 NMR spectroscopy. Incorporation of C-13-labeled glucose (Glc) is necessary to allow glycogen measurement, but might be affected by turnover changes. Our aim was to measure glycog ...

Wiley-Blackwell2008

Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study

Rolf Gruetter, Hongxia Lei

While chronic hypoglycaemia has been reported to increase unidirectional glucose transport across the blood-brain barrier (BBB) and to increase GLUT1 expression at the endothelium, the effect on steady-state brain d-glucose and brain glycogen content is cu ...

Wiley-Blackwell2006

Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T

Rolf Gruetter, Hongxia Lei

Glioma models have provided important insights into human brain cancers. Among the investigative tools, MRI has allowed their characterization and diagnosis. In this study, we investigated whether diffusion MRI might be a useful technique for early detecti ...

Wiley-Blackwell2016

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

Rolf Gruetter, Lijing Xin, Hongxia Lei, Lara Buscemi Estefanell

The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brain ...

Nature Publishing Group2014

Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose

Rolf Gruetter, Hongxia Lei, Bernard Lanz, Carole Poitry-Yamate, Antoine Timothée Cherix, Guillaume Donati, Blanca Lizarbe Serra

Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...

2021

In Vivo Metabolism of [1,6-C-13(2)]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus

Hongxia Lei, Bernard Lanz, Antoine Timothée Cherix, Rajesh Sonti

Glucose is a major energy fuel for the brain, however, less is known about specificities of its metabolism in distinct cerebral areas. Here we examined the regional differences in glucose utilization between the hypothalamus and hippocampus using in vivo i ...

2021

Neuroprotective role of lactate after cerebral ischemia

Rolf Gruetter, Pierre Magistretti, Hongxia Lei

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...

2009

Neurochemical profile of the mouse hypothalamus using in vivo1H MRS at 14.1T

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

The hypothalamus plays an essential role in the central nervous system of mammals by among others regulating glucose homeostasis, food intake, temperature, and to some extent blood pressure. Assessments of hypothalamic metabolism using, e.g. 1H MRS in mous ...

Wiley-Blackwell2010

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Rolf Gruetter, Hongxia Lei

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

2019

The neurochemical profile quantified by in vivo(1)H NMR spectroscopy

João Miguel das Neves Duarte, Rolf Gruetter, Hongxia Lei

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases wh ...

2012

Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time (1) H-MRS at 14.1 T in vivo

Rolf Gruetter, Ana Francisca Leal Silva Soares, Hongxia Lei

Alterations in the hepatic lipid content (HLC) and fatty acid composition are associated with disruptions in whole body metabolism, both in humans and in rodent models, and can be non-invasively assessed by (1) H-MRS in vivo. We used (1) H-MRS to character ...

Wiley-Blackwell2015

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Hongxia Lei, João Miguel das Neves Duarte

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

Neuronal energy metabolism in the mouse brain measured by H-1-[C-13] MRS at 14.1T under [3-C-13]-Lactate infusion: a feasibility study

Lijing Xin, Hongxia Lei, Bernard Lanz, Nicolas Kunz

SAGE PUBLICATIONS INC2019

Ultra-High Field Birdcage Coils: a Comparison Study at 14.1T

Rolf Gruetter, Arnaud Comment, Hongxia Lei, Tian Cheng

An essential feature of magnetic resonance (MR) probes for magnetic resonance imaging and spectroscopy is the ability to generate uniform B-1(+) excitation in a volume of interest. When the magnetic field strength is increased, leading to an increase in re ...

Ieee2014

Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T

Hongxia Lei, Sébastien Robert Victor Herzig

We aimed to evaluate the feasibility of neurochemical profiling of embryonic mouse brain developments in utero and to seek potential in vivo evidence of an energy shift in a mitochondrial pyruvate carrier 1 (MPC1) deficient mouse model. C57BL/6 embryonic m ...

2019

Diffusion behavior of cerebral metabolites of congenital portal systemic shunt mice assessed noninvasively by diffusion-weighted H-1 magnetic resonance spectroscopy

Hongxia Lei, Nicolas Kunz, Masoumeh Dehghani Moghadam

Diffusion-weighted H-1-MRS (DW-MRS) allows for noninvasive investigation of the cellular compartmentalization of cerebral metabolites. DW-MRS applied to the congenital portal systemic shunt (PSS) mouse brain may provide specific insight into alterations of ...

2019

Direct validation of in vivo localized 13C MRS measurements of brain glycogen

Rolf Gruetter, Hongxia Lei

With the use of localized 13C MRS in conjunction with [1-(13)C]-D-glucose infusion, it is possible to study brain glycogen metabolism in vivo. The purpose of this study was to validate in vivo 13C MRS measurements by comparing them with results from a stan ...

Wiley-Blackwell2007