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Sami Jannin

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Related publications (57)

Page 3 of 3

Ultra High-Resolution NMR: Sustained Induction Decays of Long-Lived Coherences

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Long-lived coherences (LLCs) in homonuclear pairs of chemically inequivalent spins can be excited and sustained during protracted radio frequency irradiation periods that alternate with brief windows for signal observation. Fourier transformation of the su ...

2011

Fractional Spin-Labeling of Polymers for Enhancing NMR Sensitivity by Solvent-Free Dynamic Nuclear Polarization

Andrzej Sienkiewicz, Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Wiley-Blackwell2011

Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji, David Lyndon Emsley, Aaron James Rossini

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Dynamic Nuclear Polarization and Other Magnetic Ideas at EPFL

Geoffrey Bodenhausen, Martial Rey, Sami Jannin, Aurélien Bornet, Jonas Milani, Simone Ulzega, Pascal Miéville, Marc Anthony Caporini, Nicola Salvi, Diego Carnevale, Roberto Buratto, Srinivas Chinthalapalli, Shutao Wang, Daniele Mammoli, Angel Joaquin Perez Linde

Although nuclear magnetic resonance (NMR) can provide a wealth of information, it often suffers from a lack of sensitivity. Dynamic Nuclear Polarization (DNP) provides a way to increase the polarization and hence the signal intensities in NMR spectra by tr ...

2012

Microwave frequency modulation to enhance Dissolution Dynamic Nuclear Polarization Dedicated to To Martial Rey, as a token of appreciation

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Hyperpolarization by Dissolution Dynamic Nuclear Polarization is usually achieved by monochromatic microwave irradiation of the ESR spectrum of free radicals embedded in glasses at 1.2 K and 3.35 T. Hovav et al. (2014) have recently shown that by using fre ...

Elsevier2014

Long-lived states to sustain hyperpolarized magnetization

Arnaud Comment, Jean-Philippe Ansermet, Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reserv ...

National Academy of Sciences2009

Low-temperature cross polarization in view of enhancing dissolution Dynamic Nuclear Polarization in NMR

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Dynamic Nuclear Polarization (DNP) induced by saturation of ESR transitions of TEMPO at 1.2 K and 3.35 T is characterized by build-up rates that are typically 5 times faster for protons than for the carboxylic carbon-13 in acetate. We show that cross polar ...

Elsevier2011

A magnetic tunnel to shelter hyperpolarized fluids

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Pascal Miéville, Basile Vuichoud

To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyp ...

American Institute of Physics2015

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016

Procédé de spectroscopie RMN avec dégradations d'induction prolongée de cohérences aux temps de vie longs

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A Method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprising the following steps: (a) excitation of long lived coherences (LLC) between the singlet state So and the central triplet state To of nuclei of the sample by initiating irradia ...

2014

Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Basile Vuichoud, Daniele Mammoli, Arthur César Pinon, Gabriele Stevanato

We have induced hyperpolarized long-lived states in compounds containing C-13-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyper polarized methyl long-lived states g ...

Amer Chemical Soc2017

Microwave-gated dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Xiao Ji, Arthur César Pinon, David Lyndon Emsley

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P(C-13) in short bu ...

Royal Society of Chemistry2016

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Geoffrey Bodenhausen, Sami Jannin, Jonas Milani, Estel Canet Martinez

We present novel means to hyperpolarize deuterium nuclei in (CD2)-C-13 groups at cryogenic temperatures. The method is based on cross-polarization from H-1 to C-13 and does not require any radio-frequency fields applied to the deuterium nuclei. After rapid ...

Amer Inst Physics2016

Boosting Dissolution Dynamic Nuclear Polarization by Cross Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Angel Joaquin Perez Linde

The efficiency of dissolution dynamic nuclear polarization can be boosted by Hartmann-Hahn cross polarization at temperatures near 1.2 K. This enables high throughput of hyperpolarized solutions with substantial gains in buildup times and polarization leve ...

Amer Chemical Soc2013

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyper ...

Royal Society of Chemistry2015

Toward Quantitative Measurements of Enzyme Kinetics by Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani

Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which ...

2014

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Arnaud Comment, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Cristina Ramona Cudalbu Moldovan

2008