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Harm-Anton Klok

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Related publications (195)

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

2009

Peptide/Protein−Synthetic Polymer Conjugates: Quo vadis

Harm-Anton Klok

Peptide/protein-synthetic polymer conjugates, which covalently combine one or more copies of a peptide sequence or protein with one or more synthetic polymer elements. offer unique possibilities to integrate the properties and functions of bio(macro)molecu ...

American Chemical Society2009

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

Raphaël Barbey, Harm-Anton Klok, Stefano Tugulu, Caroline Sugnaux, Dusko Paripovic, Nicolas Bertrand Schüwer

American Chemical Society2009

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

(Figure Presented) Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequen ...

Wiley-VCH Verlag GmbH2009

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

Harm-Anton Klok, Matthew Gibson

This article explores the feasibility of poly(pentafluorophenyl methacrylate) (PPFMA) prepared by reversible addition fragmentation chain transfer (RAFT) polymerization as a platform for the preparation of diverse libraries of functional polymers via postp ...

2009

Surface Modification of Polydimethylsiloxane Substrates with Nonfouling Poly(Poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Stefano Tugulu

This contribution presents a new strategy to grow nonfouling poly (poly(ethylene glycol) methacrylate) (PPEGMA) brushes from polydimethylsiloxane (PDMS) substrates. The strategy presented here is based on the use of a sequence of vapor deposition/hydrolysi ...

2009

Dendritic and hyperbranched polyamides

Harm-Anton Klok, Markus Scholl, Zuzana Kadlecova

This article discusses the synthesis and properties of dendritic and hyperbranched polyamides. The first part of the article focuses on peptide dendrimers and starts with providing an overview of the synthetic pathways that have been used to prepare dendri ...

2009

Peptide/protein – polymer conjugates: synthetic strategies and design concepts

Harm-Anton Klok, Marc Gauthier

This feature article provides a compilation of tools available for preparing well-defined peptide/protein–polymer conjugates, which are defined as hybrid constructs combining (i) a defined number of peptide/protein segments with uniform chain lengths and d ...

Royal Society of Chemistry2008

Self-organization on multiple length scales in “hairy rod”- coil block copolymer supramolecular complexes

Harm-Anton Klok

2008

Biofunctional and biomimetic polymer brushes prepared via surface-initiated atom transfer radical polymerization

Harm-Anton Klok

Surface-initiated controlled radical polymerization is a powerful strategy to tailor the chemical and physical surface properties of materials. This article highlights recent work from the author's laboratory in which surface-initiated atom transfer radica ...

2008

Stability and nonfouling properties of poly(poly(ethylene glycol) methacrylate) brushes under cell culture conditions

Harm-Anton Klok, Stefano Tugulu

American Chemical Society2008

Secondary structure formation and LCST behaviour of short, elastin-like peptides

Harm-Anton Klok, Harald Nuhn

American Chemical Society2008

pH-Sensitivity of the E3/K3 heterodimeric coiled coil

Harm-Anton Klok

American Chemical Society2008

Investigation of the Release of Bioactive Volatiles from Amphiphilic Multiarm Star-Block Copolymers by Thermogravimetry and Dynamic Headspace Analysis

John Christopher Plummer, Céline Ternat, Harm-Anton Klok

Amphiphilic multiarm star-block copolymers with a hydrophobic inner and a hydrophilic outer shell have been used to encapsulate hydrophobic bioactive volatiles in aqueous media under realistic application conditions. The release rates of the bioactive comp ...

American Chemical Society2008

The thermal polymerization of amino acids revisited; Synthesis and structural characterization of hyperbranched polymers from L-lysine

Harm-Anton Klok, Markus Scholl

This contribution reports on the synthesis of hyperbranched polylysines via thermal polymerization of L-lysine hydrochloride. Polymerization of L-lysine hydrochloride in the presence of one equivalent KOH at 150°C resulted in polymers with a number-average ...

2007

Controlling polymer architecture in the thermal hyperbranched polymerization of L-lysine

Harm-Anton Klok, Markus Scholl

Because of the unequal reactivity of the two amine groups of L-lysine hydrochloride, thermal polymerization of this asymmetrical AB2 monomer results in hyperbranched polymers, which contain ?2.5 times more N?-linked linear compared to N?-linked linear stru ...

American Chemical Society2007

Amphiphilic multi-arm star-block copolymers for encapsulation of fragrance molecules

John Christopher Plummer, Céline Ternat, Harm-Anton Klok

Novel amphiphilic multi-arm star-block copolymers with a hyperbranched core, a hydrophobic inner shell, and a hydrophilic outer shell have been prepared from a commercial hyperbranched polyester macroinitiator by ring-opening polymerization of -caprolacton ...

2007

Complex coacervate core micelles with a lysozyme-modified corona

Harm-Anton Klok, Maarten Danial

This paper describes the preparation, characterization, and enzymatic activity of complex coacervate core micelles (C3Ms) composed of poly (acrylic acid) (PAA) and poly (N- methyl-2- vinyl pyridinium iodide)-b-poly (ethylene oxide) (PQ2VP-PEO) to which the ...

2007

Thermotropic ionic liquid crystals via self-assembly of cationic hyperbranched polypeptides and anionic surfactants

Harm-Anton Klok, Markus Scholl

This work describes the dilute solution and solid-state structure of polyelectrolyte complexes generated from hyperbranched polylysine (HBPL) and various anionic, sodium alkyl sulfate surfactants. In dilute solution, the radius of gyration (Rg) of the HBPL ...

American Chemical Society2007

RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells

Nikolaos Stergiopoulos, Paolo Silacci, Harm-Anton Klok, Stefano Tugulu

This report demonstrates the feasibility of surface-initiated atom transfer radical polymerization to prepare thin polymer layers ("brushes") that can be functionalized with short peptide ligands and which may be of use as coatings to promote endothelializ ...

2007

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