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Harm-Anton Klok

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Related publications (193)

Page 3 of 10

Solution self-assembly of hybrid block copolymers containing poly(ethylene glycol) and amphiphilic peptide sequences

Harm-Anton Klok, Harald Nuhn

The self-assembly in aqueous solution of hybrid block copolymers consisting of amphiphilic ?-strand peptide sequences flanked by one or two PEG chains was investigated by means of circular dichroism spectroscopy, small-angle X-ray scattering, and transmiss ...

American Chemical Society2005

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Harm-Anton Klok, Bojana Portmann

This article reports the design, synthesis and results of first in vitro model studies of a conceptually novel class of polymer therapeutics in which the cargo is attached to a polymer backbone via a noncovalent, biologically inspired coiled coil linker, w ...

American Chemical Society2010

Ductile, High-Lignin-Content Thermoset Films and Coatings

Thanh Thi Hà Lê, Harm-Anton Klok, Alice Boarino, Nicola Carrara

In the context of transitioning toward a more sustainable use of natural resources, the application of lignin to substitute commonly utilized petroleum-based plastics can play a key role. Although lignin is highly available at low cost and presents interes ...

Amer Chemical Soc2023

Swelling-Induced Chain Stretching Enhances Hydrolytic Degrafting of Hydrophobic Polymer Brushes in Organic Media

Jian Wang, Harm-Anton Klok

Hydrophilic polymer brushes grown via surface‐initiated polymerization from silicon oxide surfaces can detach or degraft in aqueous media. Degrafting of these chain end‐tethered polymers is believed to involve hydrolysis of bonds at the polymer–substrate i ...

Wiley-VCH Verlag GmbH2019

Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Sorin Alexandru Ibanescu

Thin polymer films that prevent the adhesion of bacteria are of interest as coatings for the development of infection-resistant biomaterials. This study investigates the influence of grafting density and film thickness on the adhesion of Staphylococcus epi ...

Wiley-Blackwell2016

Polymers Interfacing with Biology

Harm-Anton Klok, Frederik Roman Wurm

The development of various controlled radical polymerization techniques as well as site- and residue specific strategies to modify peptides/proteins with synthetic polymers have made polymer chemistry a powerful tool to address materials problems at the bi ...

2011

Succinimidyl Carbonate-Based Amine-Reactive Polymer Brushes: Facile Fabrication of Functional Interfaces

Harm-Anton Klok

Polymeric coatings that can undergo effective functionalization with ligands and (bio)molecules necessary for intended applications are widely employed to engineer functional interfaces. Herein, amine-reactive polymer brushes are fabricated using a succini ...

2021

Protein Microarrays Based on Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

Harm-Anton Klok, Raphaël Barbey

Polymer brushes represent an interesting platform for the development of high-capacity protein binding surfaces. Whereas the protein binding properties of polymer brushes have been investigated before, this manuscript evaluates the feasibility of poly(glyc ...

American Chemical Society2010

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

Harm-Anton Klok, Frederik Roman Wurm, Maarten Danial

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...

2017

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

Protein microarrays are an attractive approach for the high-throughput analysis of protein function, but their impact on proteomics has been limited by the technical difficulties associated with their generation. Here we demonstrate that fusion proteins of ...

2006

Polyvalent Side Chain Peptide-Synthetic Polymer Conjugates as HIV-1 Entry Inhibitors

Harm-Anton Klok, Maarten Danial

This report describes the synthesis and properties of a series of polyvalent side chain peptide synthetic polymer conjugates designed to block the CD4 binding site on gp120 and inhibit HIV-1 entry into a host cell. The peptide sequences in the conjugates a ...

American Chemical Society2012

Nonspherical assemblies generated from polystyrene-b-poly(L-lysine) polyelectrolyte block copolymers

Harm-Anton Klok, Jutta Christine Wandrey, Markus Scholl, Laurent Bourdillon, Harald Nuhn

This report describes the aqueous solution self-assembly of a series of polystyrenem-b-poly(L-lysine)n block copolymers (m = 8-10; n = 10-70). The polymers are prepared by ring-opening polymerization of e-benzyloxycarbonyl-L-lysine AT-carboxyanhydride usin ...

2005

Functional Polymers by Post-Polymerization Modification: Concepts, Guidelines, and Applications

Harm-Anton Klok

In modern polymer science a variety of polymerization methods for the direct synthesis of polymers bearing functional groups are known. However, there is still a large number of functional groups that may either completely prevent polymerization or lead to ...

wiley2013

Maleimide-Functionalized Thiol Reactive Copolymer Brushes: Fabrication and Post-Polymerization Modification

Harm-Anton Klok, Tugba Bilgiç Tune

Polymer brushes that present side chain functional reactive groups are attractive platforms for the development of functional surface coatings. From the wide spectrum of possible postpolymerization modification reactions, thiol-based conjugation chemistrie ...

American Chemical Society2014

Investigation of the Release of Bioactive Volatiles from Amphiphilic Multiarm Star-Block Copolymers by Thermogravimetry and Dynamic Headspace Analysis

Jan-Anders Edvin Maansson, Harm-Anton Klok, John Christopher Plummer, Céline Ternat

Amphiphilic multiarm star-block copolymers with a hydrophobic inner and a hydrophilic outer shell have been used to encapsulate hydrophobic bioactive volatiles in aqueous media under realistic application conditions. The release rates of the bioactive comp ...

American Chemical Society2008

Synthesis of poly(methacrylic acid) brushes via surface-initiated atom transfer radical polymerization of sodium methacrylate and their use as substrates for the mineralization of calcium carbonate

Harm-Anton Klok, Stefano Tugulu, Raphaël Barbey

This manuscript describes the synthesis of poly(methacrylic acid) (PMAA) brushes via surface-initiated atom transfer radical polymerization (SI-ATRP) of sodium methacrylate (NaMA) and their use as substrates for the mineralization of calcium carbonate. A C ...

American Chemical Society2007

Polymer Coiled-Coil Conjugates: Potential for Development as a New Class of Therapeutic “Molecular Switch”

Harm-Anton Klok, Bojana Portmann

Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and patho ...

American Chemical Society2011

Lignin: A Sustainable Antiviral Coating Material

Francesco Stellacci, Harm-Anton Klok, Jeremy Luterbacher, Stefania Bertella, Alice Boarino, Heyun Wang, Francesca Olgiati, Melis Özkan, Nicolo' Razza

Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. Antiviral surface coatings are useful to minimize such risks. Current state-of-the-art approaches toward antiviral surface coatings eit ...

AMER CHEMICAL SOC2022

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Harm-Anton Klok, Olivier Burri, Romain Guiet, Arne Seitz, Maxime Ayer

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

2021

Exploring the Scope of the Baylis-Hillman Reaction for the Synthesis of Side-Chain Functional Polyesters

Harm-Anton Klok, Sanhao Ji

The BaylisHillman reaction provides a protective-group-free strategy to heterobifunctional polyesters, which can be further modified via various post-polymerization modification reactions. This contribution explores the BaylisHillman polymerization of 1,3- ...

2011