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Bernard Lanz

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Related publications (59)

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Marta Lai

Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution mu ...

2018

Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T

Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Antoine Timothée Cherix, Blanca Lizarbe Serra

PURPOSE: Determine the feasibility of (1) H-[(13) C] MRS in the mouse hypothalamus using a 14.1T magnet. METHODS: We optimized the design of a (1) H-[(13) C] surface coil to maximize the signal-to-noise ratio of (1) H-[(13) C] MRS in the mouse hypothalamus ...

Wiley2018

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Arnaud Comment, Sylvain Eric Lengacher, Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen, Yuhei Takado, Hikari Ananda Infinity Yoshihara

The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...

2018

In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Marta Lai, Corina Mihaela Berset

In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...

2018

MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

Bernard Lanz, Cristina Ramona Cudalbu, Veronika Rackayová

In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, a ...

Elsevier2017

Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes

Bernard Lanz, Rolf Gruetter, Marta Lai

The combination of dynamic (13)C MRS data under infusion of (13)C-labeled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific activit ...

Elsevier2017

Diffusion-weighted MRS of acetate in the rat brain

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, Masoumeh Dehghani Moghadam, Hikari Ananda Infinity Yoshihara

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Wiley-Blackwell2017

(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism

Bernard Lanz, Cristina Ramona Cudalbu, Corina Mihaela Berset, Veronika Rackayová

Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and ...

Springer Verlag2016

New technologies – new insights into the pathogenesis of hepatic encephalopathy

Bernard Lanz

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, H ...

Springer Verlag2016

Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Masoumeh Dehghani Moghadam

Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Sage Publications Ltd2016

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Bernard Lanz, Rolf Gruetter, Lijing Xin, Hongxia Lei

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate

Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS: In the present study, we took advantage of ...

Soc Nuclear Medicine Inc2014

In vivo 13C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6-13C2] Glucose

Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu, Carola Jaquelina del Carmen Romero, Marta Lai

2014

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Bernard Lanz, Rolf Gruetter, Lijing Xin

Astrocytes have recently become a major center of interest in neurochemistry with the discoveries on their major role in brain energy metabolism. An interesting way to probe this glial contribution is given by in vivo 13C NMR spectroscopy coupled with the ...

Wiley-Blackwell2014

Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1H-MRS longitudinal study at 14.1T

Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu, Marta Lai

2014

Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

The recent developments in high magnetic field (13) C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of (13) C in vivo spectra in the rodent brain, enabl ...

Wiley-Blackwell2013

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte

Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way. Beside the measurement of the total ...

2013

Hepatic glucose sensing is required to preserve β cell glucose competence

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Frédéric Schütz

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents

Bernard Lanz

Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...

EPFL2012

A two-compartment mathematical model of neuroglial metabolism using [1-C-11] acetate

Bernard Lanz, Rolf Gruetter

The purpose of this study was to develop a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-C-11] acetate radiotracer experiments, using an approach previously applied in C-13 magnetic resonance spectroscopy (MRS), ...

Nature Publishing Group2012

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