Publication

Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

Rolf Gruetter, Vladimir Mlynarik, Bernard Lanz, Carole Poitry-Yamate
2011
Journal Articles

Abstract

3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [F-18]FLT in tumor xenografts.

Official source

https://infoscience.epfl.ch/entities/publication/fcd18b0c-4ced-48fe-adea-5c2cbaf141ca

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Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

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