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Henry Markram

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Related publications (169)

Identifying, tabulating, and analyzing contacts between branched neuron morphologies

Simulating neural tissue requires the construction of models of the anatomical structure and physiological function of neural microcircuitry. The Blue Brain Project is simulating the microcircuitry of a neocortical column with very high structural and phys ...

2008

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

Henry Markram, Michele Pignatelli, Thomas Berger, Michele Giugliano, Corrado Cali

Electrical synapses continuously transfer signals bi-directionally from one cell to another, directly or indirectly via intermediate cells. Electrical synapses are common in many brain structures such as the inferior olive, the subcoeruleus nucleus and the ...

Springer US2008

Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons

Alain Destexhe, Henry Markram

We review here the development of Hodgkin-Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected th ...

2008

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

Henry Markram

Neuroscience produces a vast amount of data from an enormous diversity of neurons. A neuronal classification system is essential to organize such data and the knowledge that is derived from them. Classification depends on the unequivocal identification of ...

2008

Slow oscillations in neural networks with facilitating synapses

Henry Markram, Gilad Silberberg

The synchronous oscillatory activity characterizing many neurons in a network is often considered to be a mechanism for representing, binding, conveying, and organizing information. A number of models have been proposed to explain high-frequency oscillatio ...

Springer US2008

Abnormal fear conditioning and amygdala processing in an animal model of autism

Tania Rinaldi, Deborah La Mendola, Henry Markram, Maria del Carmen Sandi Perez, Kamila Markram

A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...

Nature Publishing Group2008

Industrializing neuroscience

Henry Markram

2007

Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity

Henry Markram

The patch-clamp technique has allowed detailed studies on the electrical properties of neurons. Dye loading through patch pipettes has allowed characterizing the morphological properties of the neurons. In addition, the patch-clamp technique also allows ha ...

Springer2007

A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data

Henry Markram, Idan Segev

We present a novel framework for automatically constraining parameters of compartmental models of neurons, given a large set of experimentally-measured responses of these neurons. In experiments, intrinsic noise gives rise to a large variability (e.g., in ...

2007

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells

Henry Markram, Gilad Silberberg

Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcirc ...

2007

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Tania Rinaldi, Henry Markram, Gilad Silberberg

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2007

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

Luca Gambazzi, Henry Markram, Michele Giugliano

The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic ...

2007

The intense world syndrome – an alternative hypothesis for autism

Tania Rinaldi, Henry Markram, Kamila Markram

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007

Methods For Treating And/Or Preventing Pervasive Developmental Disorders In A Subject

Tania Rinaldi, Henry Markram, Karina Kulangara

The present invention concerns a method for treating and/or preventing a Pervasive Developmental Disorder in a subject in need thereof comprising the step of modulating the synaptic connectivity in the neocortex by administering a therapeutically effective ...

2007

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Tania Rinaldi, Henry Markram, Karina Kulangara

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

National Academy of Sciences2007

Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex

Jean-Vincent Le Bé, Henry Markram, Gilad Silberberg, Yi Wang

Neocortical pyramidal cells (PCs) project to various cortical and subcortical targets. In layer V, the population of thick tufted PCs (TTCs) projects to subcortical targets such as the tectum, brainstem, and spinal cord. Another population of layer V PCs p ...

Oxford University Press2007

Spontaneous and evoked synaptic rewiring in the neonatal neocortex

Jean-Vincent Le Bé, Henry Markram

The local microcircuitry of the neocortex is structurally a tabula rasa, with the axon of each pyramidal neuron having numerous submicrometer appositions with the dendrites of all neighboring pyramidal neurons, but is functionally highly selective, with sy ...

National Academy of Sciences2006

Parallel network simulations with NEURON

Henry Markram

The NEURON simulation environment has been extended to support parallel network simulations. Each processor integrates the equations for its subnet over an interval equal to the minimum (interprocessor) presynaptic spike generation to postsynaptic spike de ...

2006

Heterogeneity in the pyramidal network of the medial prefrontal cortex

Henry Markram, Thomas Berger, Yi Wang

The prefrontal cortex is specially adapted to generate persistent activity that outlasts stimuli and is resistant to distractors, presumed to be the basis of working memory. The pyramidal network that supports this activity is unknown. Multineuron patch-cl ...

2006

Un nouveau mécanisme de mémoire : connexions et déconnexions de neurones dans le néocortex de jeunes rats [A new mechanism for memory: neuronal networks rewiring in the young rat neocortex]

Jean-Vincent Le Bé, Henry Markram

2006

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