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Paul Joseph Dyson

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Related publications (669)

Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

Hubert van den Bergh, Georges Wagnières, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Angela Casini

The antimetastatic ruthenium (II) compounds [Ru(eta(6)-p-cymene)Cl-2(PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) and [Ru(eta(6)-toluene)Cl-2(PTA)] (RAPTA-T), as well as their analogues [Ru(eta(6)-p-cymene)Cl-2(DAPTA)] (DAPTA = (3,7-diacetyl-1, ...

2011

Metal-based antitumour drugs in the post-genomic era: what comes next?

Paul Joseph Dyson, Gianni Sava

In our Dalton Transactions Perspective article entitled, 'Metal-based antitumour drugs in the post genomic era', (Dalton Trans., 2006, 1929-1933) we discussed metal-based drugs in light of past decades of research. We concluded that the post-genomic era wo ...

2011

Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Paul Joseph Dyson, Alexey Nazarov

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic acti ...

Oxford University Press2011

Modulating the Steric, Electronic, and Catalytic Properties of Cp* Ruthenium Half-Sandwich Complexes with β-Diketiminato Ligands

Kay Severin, Rosario Scopelliti, Paul Joseph Dyson, Dominique Schreiber, Katrin Anne Thommes, Andrew Douglas Phillips

Five different types of β-diketiminate ligands, bearing electron-donating to strongly electron-withdrawing substituents, were synthesized and used in the synthesis of Cp* ruthenium complexes (Cp* = η5-C5Me5). One series consists of complexes with a covalen ...

American Chemical Society2011

Defunctionalization of fructose and sucrose: Iron-catalyzed production of 5-hydroxymethylfurfural from fructose and sucrose

Paul Joseph Dyson, Ning Yan, Yuehui Li

A highly efficient iron-catalyzed production of 5-hydroxymethylfurfural (HMF) from sugar is reported. The dehydration of fructose and sucrose has been studied in the presence of different iron salts and co-catalysts. As a result, it was found that fructose ...

Elsevier2011

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties

Paul Joseph Dyson, Angela Casini, Dennis Snelders, Fabio Edafe

The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl-2(L) (L - oligocationic phosphine), are reported. The complexes are ...

2011

Styrene oxidation by hydrogen peroxide in ionic liquids: the role of the solvent on the competition between two Pd-catalyzed processes, oxidation and dimerization

Paul Joseph Dyson, Cinzia Chiappe

A series of hydrophilic N,N-dimethylpyrrolidinium-and N,N-dimethylpiperidinium-based ionic liquids (ILs) have been prepared and applied as reaction media in the Wacker oxidation of styrene by hydrogen peroxide using PdCl2 as the catalyst. The efficiency of ...

2011

Influence of arene dissociation and phosphine coordination on the catalytic activity of [RuCl(kappa(2)-triphos)(p-cymene)]PF6

Paul Joseph Dyson

The catalytic activity of a ruthenium(II)-p-cymene complex containing a partially coordinated triphosphine ligand, [RuCl(kappa(2)-triphos)(p-cymene)]PF6 1, has been investigated in the hydrogenation of styrene to ethylbenzene. The influence of arene dissoc ...

2011

Supported nitrogen-modified Pd nanoparticles for the selective hydrogenation of 1-hexyne

Lioubov Kiwi, Gabor Laurenczy, Paul Joseph Dyson, Rocio Micaela Crespo Quesada, Ryan Dykeman

2,2′-Bipyridine (bipy) and an imidazolium-functionalized bipy ligand were used in the synthesis of palladium nanoparticles in water and in ionic liquid. The function of such ligands was twofold: first, as stabilizing agents to prevent the agglomeration of ...

2011

Non-essential metals in chemical biology

Paul Joseph Dyson

Metal ions and compounds are essential to life and many people routinely take them as food supplements in the form of vitamin and mineral pills. Most non-essential metals are considered to be toxic, nevertheless, many are widely used in imaging, diagnostic ...

2011

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

2011

Mass Spectrometric and Theoretical Study of Polyiodides: The Connection between Solid State, Solution, and Gas Phases

Paul Joseph Dyson, Zhaofu Fei, Michael Groessl

Polyiodides have been transferred intact from acetonitrile solution to the gas phase and analyzed by mass spectrometry. A range of ions were observed, including I-11, I-13, and I-15, which have higher iodine/iodide ratios than any previously ...

2011

Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes bearing the 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand, namely, RAPTA compounds, are widely investigated as potential antimetastatic agents for cancer therapy. Although much evidence points toward covalent binding with ...

American Chemical Society2011

Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

Paul Joseph Dyson, Olivier Pierre Zava

A series of large cationic hexanuclear metalla-prisms, Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3), Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3) and Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3), composed of p-cymene-ruthenium building blocks brid ...

2011

Organometallic Chemistry in Non-Classical Environments

Paul Joseph Dyson

A summary of our on-going research on organometallic chemistry is provided with an emphasis on the function, reactivity and mechanisms of organometallic compounds in water, ionic liquids and in living systems. The role of organometallic compounds in both c ...

2011

Efficient Dehydrogenation of Formic Acid Using an Iron Catalyst

Gabor Laurenczy, Paul Joseph Dyson, Matthias Beller

Hydrogen is one of the essential reactants in the chemical industry, though its generation from renewable sources and storage in a safe and reversible manner remain challenging. Formic acid (HCO2H or FA) is a promising source and storage material in this r ...

American Association for the Advancement of Science2011

Synthesis of Gold Nanoparticle Catalysts Based on a New Water-Soluble Ionic Polymer

Gabor Laurenczy, Paul Joseph Dyson, Ilaria Biondi

A new water-soluble methyl-imidazolium-based ionic polymer was synthesized by ring-opening metathesis polymerization that was subsequently used to prepare aqueous gold nanoparticle solutions which were characterized by UVvis spectroscopy and transmission e ...

2011

pH-Sensitive Gold Nanoparticle Catalysts for the Aerobic Oxidation of Alcohols

Paul Joseph Dyson, Ning Yan, Yuan Yuan

Gold nanoparticles (NPs) stabilized by carboxylate modified polyvinylpyrrolidone have been prepared and fully characterized. The gold NPs efficiently catalyze the aerobic oxidation of benzyl alcohol in water at ambient temperature and are easily separated ...

2011

Application of Ionic Liquids Containing Tricyanomethanide [C(CN)(3)](-) or Tetracyanoborate [B(CN)(4)](-) Anions in Dye-Sensitized Solar Cells

Michael Graetzel, Shaik Mohammed Zakeeruddin, Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Magdalena Anna Marszalek

A series of novel ionic liquids composed of imidazolium, pyridinium, pyrrolidinium, and ammonium cations with tricyanomethanide or tetracyanoborate anions were prepared. The ionic liquids were characterized by NMR and IR spectroscopy and ESI-mass spectrome ...

2011

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Paul Joseph Dyson

2011

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