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Kay Severin

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Related publications (205)

Page 2 of 11

Covalent Capture of Nitrous Oxide by N-Heterocyclic Carbenes

Rosario Scopelliti, Kay Severin, Matthew Wodrich, Euro Solari, Alexander Tskhovrebov

A good catch: N-heterocyclic carbenes (NHCs) form stable adducts with nitrous oxide (N2O) under mild reaction conditions. The adducts display unique reactivity as evidenced by an alkylation reaction which leads to a rupture of the NN bond. ...

Wiley-Blackwell2012

Ruthenium-Catalyzed Sequential Enyne Cross-Metathesis/ATRA Reactions

Kay Severin, Euro Solari, Gregor Kiefer, Jesus Ruiz

Sequential enyne cross-metathesis reactions of arylalkynes with ethylene followed by atom transfer radical addition (ATRA) with ethyl dichloroacetate or dichloroacetonitrile provide 1,5-dichloropent-2-ene derivatives. The second-generation Grubbs alkyliden ...

Wiley-Blackwell2012

Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes

Rosario Scopelliti, Kay Severin, Nicolai Cramer, Gregor Kiefer, Abdusalom Suleymanov, David Kossler, Florian Gérald Abela

Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1-alkynyl triazenes in the presence of a RuII catalyst with a chiral cyclopentadienyl ligand. These triazenes serve as unique vinyl cation surrogates. ...

Wiley-VCH Verlag GmbH2017

Beyond Click-Chemistry: Transformation of Azides with Cyclopentadienyl Ruthenium Complexes

Rosario Scopelliti, Kay Severin, Julie Risse

The cyclopentadienyl Ru complexes CpRuCl(cod) (cod = 1,5-cyclooctadiene), CpRuCl(PPh3)2, and [CpRuCl2]2 (Cp = η5-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) are able to catalyze the decomposition of benzyl azides to give 1,3,5-triphenyl-2,4- ...

American Chemical Society2011

Array-based sensing of purine derivatives with fluorescent dyes

Kay Severin, Ziya Köstereli

Natural and synthetic purine derivatives such as caffeine, theophylline, 6-mercaptopurine and 8-chlorotheophylline are important drugs. Due to the structural similarity of these compounds, it is intrinsically difficult to prepare chemosensors for their sel ...

Royal Soc Chemistry2015

Nitrous oxide as diazo transfer reagent

Kay Severin, Alexandre Tcheul-Young Genoux

Nitrous oxide, commonly known as "laughing gas", is formed as a by-product in several industrial processes. It is also readily available by thermal decomposition of ammonium nitrate. Traditionally, the chemical valorization of N 2 O is achieved via oxidati ...

Royal Society of Chemistry (RSC)2024

Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

Rosario Scopelliti, Kay Severin, Ziya Köstereli

A mixture of two amphiphiles with fluorescent head groups can be used as a sensing ensemble for the pattern-based analysis of aminoglycoside antibiotics. In buffered aqueous solution, the amphiphiles form a dynamic mixture of micellar aggregates. In the pr ...

Royal Soc Chemistry2014

A Fluorescent Sensor for Pyrophosphate Based on a Pd(II) Complex

Rosario Scopelliti, Kay Severin

A mixture of the Pd(II) complex [Pd(NO3)2(bipy)] (bipy = 2,2-bipyridine) and the fluorescent dye Methylcalcein blue (MCB) constitutes a chemosensing ensemble which can be used for the detection of pyrophosphate (PPi) by fluorescence spectroscopy. The senso ...

Royal Society of Chemistry2010

Supramolecular polymers based on dative boron–nitrogen bonds

Kay Severin, Nicolas Luisier, Erin Sheepwash

Heteroditopic monomers containing an arylboronate ester and a dialkyl-4-aminopyridine group aggregate via dative boron–nitrogen bonds to give main chain supramolecular polymers. The degree of polymerization can be tuned by changing the electronic and steri ...

Royal Society of Chemistry2012

Alkynyl triazenes enable divergent syntheses of 2-pyrones

Kay Severin, Nicolai Cramer, Carl Thomas Bormann, Jin Fay Tan

The 2-pyrone motif occurs frequently in bioactive natural products and is appreciated as synthetic intermediates. However, only few methods allow for diversifying functional group modifications on this relevant heterocycle. The distinct properties of 1-alk ...

2021

Chemo- and regio-divergent access to fluorinated 1-alkyl and 1-acyl triazenes from alkynyl triazenes

Kay Severin, Nicolai Cramer, Carl Thomas Bormann, Jin Fay Tan

The 1,1,2,2-tetrafluoroethylene unit is prevalent in bioactive molecules and functional materials. Despite being in principle a straightforward strategy to access this motif, the direct tetrafluorination of alkynes involves very hazardous or inconvenient r ...

2022

Constitutionally selective amplification of multicomponent 84-membered macrocyclic hosts for (−)-cytidine•H+

Kay Severin

Mixtures of dipeptide monomers create stereochemically and constitutionally complex dynamic libraries of potential receptors. When (−)-cytidine was utilized as guest an 84-membered cyclic host was amplified (70–175 fold) from a nearly undetectable initial ...

2011

Formation of Boronate Ester Polymers with Efficient Intrastrand Charge Transfer Transitions by Three-Component Reactions

Rosario Scopelliti, Kay Severin, Ursula Röthlisberger, Michele Cascella, Nicolas Christinat, Emmanuel Croisier

The three-component reaction of aryl boronic acids with 1,2,4,5-tetrahydroxybenzene and 1,2-bis(4-pyridyl)ethylene or 4,4-bipyridine leads to the formation of dark-purple boronate ester polymers. Crystallographic analyses show that the polymer strands have ...

2007

The acid-mediated isomerization of iridium(iii) complexes with cyclometalated NHC ligands: kinetic vs. thermodynamic control

Kay Severin, Farzaneh Fadaei Tirani, Anastasia Gitlina

The isomerization of iridium(III) complexes with metalated N-heterocyclic carbene (NHC) ligands was studied. The fac isomers of complexes with 1-phenyl-3-methylbenzimidazolin-2-ylidene or 1-phenyl-3-benzylbenzimidazolin-2-ylidene ligands are transformed cl ...

2023

The Intricate Chemistry of Cobalt(II) Halides and Bis(diphenylphosphanyl)ethane

Rosario Scopelliti, Kay Severin, Heron Vrubel, Gregor Kiefer

Phosphane complexes of the putative formula [CoX2(dppe)] [X = Cl, Br, I; dppe = bis(diphenylphosphanyl)ethane] are frequently used catalyst precursors in cobalt-catalyzed reactions. Despite their widespread use, these complexes have not been structurally c ...

Wiley-Blackwell2013

Pattern-Based Sensing of Short Oligodeoxynucleotides with Palladium–Dye Complexes

Kay Severin, Anton Granzhan

The colorimetric response of a sensor array composed of palladium–dye complexes can be used to identify different hexadeoxynucleotides and to distinguish mixtures of sequence-isomeric hexadeoxynucleotides. ...

Royal Society of Chemistry2010

Utilization of Self-Sorting Processes to Generate Dynamic Combinatorial Libraries with New Network Topologies

Rosario Scopelliti, Kay Severin

The synthesis of water-sol., organometallic macrocycles is described. They were obtained by self-assembly in reactions of the half-sandwich complexes [{Ru(C6H5Me)Cl2}2], [{Ru(p-cymene)Cl2}2], [{Rh(Cp)Cl2}2], and [{Ir(Cp*)Cl2}2] with the ligand 5-dimethylam ...

2006

Stabilization of molecular LiF, LiFHF, and Na2SiF6 using metallamacrocyclic hosts

Kay Severin, Marie-Line Lehaire

The molecular forms of LiF, LiFHF and Na2SiF6 have been stabilized using trinuclear metallamacrocyclic complexes of (cymene)Ru-II, (Cp*)Rh-III and (Cp*)Ir-III as specific receptors. The host-guest complexes were characterized by NMR spectroscopy and single ...

2003

A solvent-responsive coordination cage

Rosario Scopelliti, Kay Severin, Benan Kilbas

The solvent-induced structural rearrangement of synthetic supramolecular structures typically requires a pronounced change in solvent polarity. We describe a ruthenium-based coordination cage, whose geometry and topology can be altered dramatically by usin ...

2012

Homogeneous catalysis with nitrous oxide

Kay Severin

Nitrous oxide (N2O; ‘laughing gas’) is a powerful oxidant, but chemical transformations are hampered by the inert character of this gas. Recent advances in using N2O as an oxidant in metal-catalyzed reactions are discussed. The focus will be on reactions t ...

2023