Course

PHYS-441: Statistical physics of biomacromolecules

Summary

Biological macromolecules such as DNA, RNA, proteins and cytoskeletal filaments are polymers. As such, they share a set of properties that are common to any polymer, which are the focus of this course. Details about the protein folding problem will be covered in the last part.

Lectures

Instructor

Paolo De Los Rios

Paolo De Los Rios earned his master in Electronic Engineering at the Turin Institute of Technology (Politecnico di Torino) in May 1993. In November 1993 he moved to Trieste, Italy, to enter the PhD program in Theoretical Condensed Matter Theory at the International School for Advanced Studies (SISSA/ISAS) where he obtained the PhD degree in October 1996 for his work on the statistical physics of disordered systems. After a one year postdoc at the Max-Planck Institute for the Physics of Complex Systems in Dresden, Germany, in November 1997 he moved to the University of Fribourg, Switzerland, to join the group of Prof. Yi-Cheng Zhang. There he has worked on various applications of statistical physics to complex systems. In September 2000 he has been appointed Assistant Professor in Statistical Physics of Living Matter and Complex Systems at the Institute of Theoretical Physics of the University of Lausanne, Switzerland. Since April 2010 he is Associate Professor at the Institute of Theoretical Physics of the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

Official source

https://edu.epfl.ch/coursebook/en/statistical-physics-of-biomacromolecules-PHYS-441

Moodle Page

http://go.epfl.ch/PHYS-441

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Summary

Lectures

Instructor

Paolo De Los Rios

Official source

https://edu.epfl.ch/coursebook/en/statistical-physics-of-biomacromolecules-PHYS-441

Moodle Page

http://go.epfl.ch/PHYS-441

Lectures in this course (28)

Polymer Structure and Biological Relevance

Covers the molecular structure of polymers, the transcription process, and the implications of protein misfolding in diseases.

Central Dogma: DNA, RNA, Proteins

Covers the central dogma of molecular biology, focusing on DNA, RNA, and proteins.

Polymer Models: Basic Observables

Introduces basic observables and simple models in polymer science, emphasizing the importance of reproducible measurements and discussing the concept of one-dimensional polymers.

Cytoskeleton: Actin Filaments and Microtubules

Explores actin filaments, microtubules, monomers, proteins, dimer formation, and protein aggregation in the cytoskeleton.

Polymer Theory: End-to-End Distance

Explores the calculation of end-to-end distance in polymer theory, focusing on isotropy, probability distributions, and the Kratky-Porod model.

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