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Jeffrey Alan Hubbell

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Related publications (229)

Engineering Interactions between Growth Factors and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Esra Güç

Federation Amer Soc Exp Biol2015

Conjugates containing sequences from placenta growth factor and their use as components of biomaterials and in medicine

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, an ...

2015

High aspect ratio nanofibril materials

Jeffrey Alan Hubbell, Carrie Ellen Brubaker

The present invention features linear and three-dimensional supramolecular materials self-assembled from block copolymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials a ...

2015

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

Mikaël Martino, Jeffrey Alan Hubbell, Alice Anna Tomei

With a view toward reduction of graft loss, we explored pancreatic islet transplantation within fibrin matrices rendered pro-angiogenic by incorporation of minimal doses of vascular endothelial growth factor-A165 and platelet-derived growth factor-BB prese ...

Wiley-Blackwell2015

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Mikaël Martino, Jeffrey Alan Hubbell, Alexandre de Titta, Ziad Julier, Laura Jeanbart

Fibronectin (FN) is an extracellular matrix (ECM) protein including numerous fibronectin type III (FNIII) repeats with different functions. The alternatively spliced FN variant containing the extra domain A (FNIII EDA), located between FNIII 11 and FNIII 1 ...

Nature Publishing Group2015

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...

Wiley-Blackwell2015

Conformal Coating of Islets of Langerhans: a Microfluidic Approach for Transplantation Without Immunosuppression

Jeffrey Alan Hubbell, Alice Anna Tomei

Mary Ann Liebert, Inc2014

Clonal, Self-Renewing and Differentiating Human and Porcine Urothelial Cells, a Novel Stem Cell Population

Jeffrey Alan Hubbell, Yann Barrandon, Peter Frey, Hans Mattias Larsson, François Gorostidi

Although urothelial progenitor-like cells have been described in the human urinary tract, the existence of stem cells remains to be proven. Using a culture system that favors clonogenic epithelial cell growth, we evaluated and characterized clonal human ur ...

Public Library of Science2014

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Stéphanie Elisabeth Metzger, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Jeffrey James Rice, Esra Güç, Federico Tortelli

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

American Association for the Advancement of Science2014

Extracellular matrix molecules regulate growth factor and cytokine delivery through their heparin-binding domains and promote wound healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Wiley-Blackwell2014

Human and porcine urothelial stem cells

Jeffrey Alan Hubbell, Yann Barrandon, Peter Frey, Hans Mattias Larsson, François Gorostidi

Wiley-Blackwell2014

Normalization and accelerated stabilization of VEGF-induced angiogenesis by co-delivery of engineered PDGF-BB and VEGF proteins from fibrin matrices

Mikaël Martino, Jeffrey Alan Hubbell, Veronica Sacchi

Wiley-Blackwell2014

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Patricia Corthésy Henrioud, Pedro Romero, Laura Jeanbart

The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against ...

Amer Assoc Cancer Research2014

Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone

Nicola Tirelli, Jeffrey Alan Hubbell

PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on ...

Wiley-V C H Verlag Gmbh2014

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Mikaël Martino, Jeffrey Alan Hubbell, Kristen Lorentz, Elena Groppa, Martin Ehrbar, Veronica Sacchi

Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Re ...

National Academy of Sciences2014

Growth factors engineered for super-affinity to extracellular matrix enhance tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Witold Waldemar Kilarski, Federico Tortelli

Wiley-Blackwell2014

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Mikaël Martino, Jeffrey Alan Hubbell

In this work we have evaluated the capacity of bone morphogenetic protein-2 (BMP-2) and fibrin-binding platelet-derived growth factor-BB (PDGF-BB) to support cell growth and induce bone regeneration using two different imaging technologies to improve the u ...

Elsevier Sci Ltd2014

Cytoplasmic Stopped Flow at the Single Cell Level Based on Photosensitive Polymersomes

Jeffrey Alan Hubbell, Conlin O'Neil, Demetri Psaltis, Andreas Vasdekis

Cell Press2014

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

Jeffrey Alan Hubbell, Melody Swartz, Susan Thomas, Amanda Waite Lund, Efthymia Vokali

Accumulating evidence implicates the tumor-draining lymph node (TDLN) in tumor-induced immune escape, as it drains regulatory molecules and leukocytes from the tumor microenvironment. We asked whether targeted delivery of adjuvant to the TDLN, presumably a ...

Elsevier Sci Ltd2014

Overcoming immunological barriers in regenerative medicine

Jeffrey Alan Hubbell

Regenerative therapies that use allogeneic cells are likely to encounter immunological barriers similar to those that occur with transplantation of solid organs and allogeneic hematopoietic stem cells (HSCs). Decades of experience in clinical transplantati ...

Nature Publishing Group2014

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