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Jeffrey Alan Hubbell

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Related publications (229)

Therapeutic Angiogenesis by Short-Term Co-Delivery of Fibrin-Bound VEGF and PDGF-BB Proteins

Mikaël Martino, Jeffrey Alan Hubbell, Veronica Sacchi

Mary Ann Liebert, Inc2015

Culture of preantral follicles in poly(ethylene) glycol-based, three-dimensional hydrogel: a relationship between swelling ratio and follicular developments

Jeffrey Alan Hubbell, Seung Tae Lee

This study was undertaken to examine how the softness of poly(ethylene) glycol (PEG)-based hydrogels, creating a three-dimensional (3D) microenvironment, influences the in vitro growth of mouse ovarian follicles. Early secondary, preantral follicles of 2we ...

Wiley-Blackwell2015

Murine ovarian follicle culture in PEG-hydrogel: Effects of mechanical properties and the hormones FSH and LH on development

Jeffrey Alan Hubbell, Jong Eun Ihm, Seung Tae Lee

The development of an in vitro culture system, comparable to the in vivo environment in terms of effects on oocyte growth and development, could provide a valuable experimental tool for studying the mechanisms governing oocyte development as well as practi ...

Polymer Soc Korea2015

Engineering antigen-specific immunological tolerance

Jeffrey Alan Hubbell, Stephane Kontos, Alizée Jéléna Grimm

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We pr ...

Current Biology Ltd2015

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Jeffrey Alan Hubbell, Davide Demurtas, Carrie Ellen Brubaker, Edward Allen Phelps

With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrop ...

Amer Chemical Soc2015

Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Elif Vardar, Mouti Elodie Mouloungui, Kalitha Pinnagoda

Ureteral replacement by tissue engineering might become necessary following tissue loss after excessive ureteral trauma, after retroperitoneal cancer, or even after failed reconstructive surgery. This need has driven innovation in the design of novel scaff ...

Mary Ann Liebert, Inc2015

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Jeffrey Alan Hubbell, Stephane Kontos, Alizée Jéléna Grimm, Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri

New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with apoptotic debris are known to be processed tolerogenically ...

Nature Publishing Group2015

Engineering Interactions between Morphogens and the Extracellular Matrix

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Mary Ann Liebert, Inc2015

Short-Term Delivery of Fibrin-Bound VEGF Protein in Osteogenic Grafts ensures both Increased Vascularization and Efficient Bone Formation

Jeffrey Alan Hubbell, Veronica Sacchi

Mary Ann Liebert, Inc2015

Off-the Shelf Collagen-fibrin based Scaffolds for Bladder Augmentation

Jeffrey Alan Hubbell, Peter Frey, Eva-Maria Balet, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda

Mary Ann Liebert, Inc2015

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Jeffrey Alan Hubbell, Melody Swartz, Iraklis Kourtis, Laura Jeanbart

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress effector T cell responses and can reduce the efficacy of cancer immunotherapies. We previously showed that ultra-small polymer nanoparticles eff ...

Springer2015

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

Collagen Based Tubular Structures for Urethral Repair in a Rabbit Model

Jeffrey Alan Hubbell, Peter Frey, Eva-Maria Balet, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Ganesh Vythilingam

Mary Ann Liebert, Inc2015

Kinetics of Ultrasonic Drug Delivery from Targeted Micelles

Jeffrey Alan Hubbell

To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug relea ...

Amer Scientific Publishers2015

Improved biocompatibility of polyethylenimine (PEI) as a gene carrier by conjugating urocanic acid: In vitro and in vivo

Jeffrey Alan Hubbell, Jong Eun Ihm, Irina Krier

Polyethylenimine (PEI) is a promising gene carrier among polymeric vectors because of its high transfection efficiency, buffering capacity, which is responsible for its escape from endosomes, facility of modification, reasonable price and wide range of mol ...

Polymer Soc Korea2015

TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma

Jeffrey Alan Hubbell, Eleonora Simeoni, Martina Damo, David Scott Wilson

Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet res ...

Nature Publishing Group2015

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Benjamin John Marsland

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

Extracellular matrix heparin-binding domains

Mikaël Martino, Jeffrey Alan Hubbell, Jeffrey James Rice, Federico Tortelli

Heparin binding peptides derived from a Tenascin (TNC) III1-5 domain or a fibrinogen ²15-66 domain have been found that bind certain cytokines with high affinity. Materials and methods for making compositions and devices using these peptides are disclosed. ...

2015

Prescription for a pharmacyte

Jeffrey Alan Hubbell

Amer Assoc Advancement Science2015

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiologic ...

Elsevier Science Bv2015

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