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Jeffrey Alan Hubbell

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Related publications (227)

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PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin A as an example

Jeffrey Alan Hubbell, Davide Demurtas

Micelles formed from amphiphilic block copolymers have been explored in recent years as carriers for hydrophobic drugs. In an aqueous environment, the hydrophobic blocks form the core of the micelle, which can host lipophilic drugs, while the hydrophilic b ...

2008

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Jeffrey Alan Hubbell, Melody Swartz, Priscilla Suhasna Maithili Briquez, Esra Güç, Manuel Andreas Fankhauser

Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...

2017

Molecularly engineered PEG hydrogels: A novel model system for proteolytically mediated cell migration

Jeffrey Alan Hubbell, Matthias Lütolf

Model systems mimicking the extracellular matrix (ECM) have greatly helped in quantifying cell migration in three dimensions and elucidated the mol. determinants of cellular motility in morphogenesis, regeneration, and disease progression. Here the authors ...

2005

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche

Jeffrey Alan Hubbell, Yun Suk Jo

We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin- specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin ...

Elsevier2010

Engineered insulin-like growth factor-1 for improved smooth muscle regeneration

Jeffrey Alan Hubbell, Peter Frey

Insulin-like growth factor-1 (IGF-1) has been shown to induce potent mitogenic responses in various cell types, yet its sustained local delivery is still an underdeveloped domain in the clinic. We report here an engineered IGF-1 that facilitates extended l ...

2012

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Alizée Jéléna Grimm, Ziad Julier

Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...

Elsevier Sci Ltd2016

In situ cell manipulation through enzymatic hydrogel photopatterning

Jeffrey Alan Hubbell, Matthias Lütolf, Katarzyna Mosiewicz, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013

Biomimetic PEG hydrogels crosslinked with minimal plasmin-sensitive tri-amino acid peptides

Jeffrey Alan Hubbell, Matthias Lütolf

Semi-synthetic, proteolytically degradable polymer hydrogels have proven effective as scaffolds to augment bone and skin regeneration in animals. However, high costs due to expensive peptide building blocks pose a significant hurdle towards broad clinical ...

Wiley-Blackwell2009

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

A collagen-poly(lactic acid-co-epsilon-caprolactone) hybrid scaffold for bladder tissue regeneration

Jeffrey Alan Hubbell, Florian Maria Wurm, Peter Frey

Scaffold materials should favor cell attachment and proliferation, and provide designable 3D structures with appropriate mechanical strength. Collagen matrices have proven to be beneficial scaffolds for tissue regeneration. However, apart from small intest ...

2011

PPS-PEG surface coating to reduce thrombogenicity of small diameter ePTFE vascular grafts

Jeffrey Alan Hubbell

Aims: Patency failure of small vascular synthetic grafts is still a major problem for coronary and peripheral revascularization. Thus, three new surface coatings of small synthetic grafts were tested in an acute pig model to evaluate their thrombogenicity ...

2005

Quantitative intrinsic auto-cathodoluminescence can resolve spectral signatures of tissue-isolated collagen extracellular matrix

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Elif Vardar, Marcin Stefan Zielinski

By analyzing isolated collagen gel samples, we demonstrated in situ detection of spectrally deconvoluted auto-cathodoluminescence signatures of specific molecular content with precise spatial localization over a maximum field of view of 300 mu m. Correlati ...

2019

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

Jeffrey Alan Hubbell, Jennifer Patterson

Bioactive hydrogels formed by Michael-type addition reactions of end-functionalized poly(ethylene glycol) macromers with cysteine-containing peptides have been described as extracellular matrix mimetics and tissue engineering scaffolds. Although these mate ...

Elsevier2010

SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels

Jeffrey Alan Hubbell

Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic r ...

2011

Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

Jeffrey Alan Hubbell

Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropri ...

2008

Cell-responsive hydrogel for encapsulation of vascular cells

Jeffrey Alan Hubbell

The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...

2009

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

Jie Gao, Caroline Antonioli Pletscher, Emilie Jocelyne Marc Solange Collot, Mathias Béguin, Beat Mueller, Abdel Perez Hernandez, Dora Patricia Valente Salgueiro, Michael Andrew Theodore Fowler, Tobias Hurth, Yi Zhang, Jan Steggemann, Hua Zhang, Elena Graverini, Jeffrey Alan Hubbell, Pierluigi Bruzzone, Jean-Michel Sallese, Mingkui Wang, Luca Rossi, Mikhail Chapochnikov, Thomas Rizzo, Rui Ning Wang, Mathias Oleg Knecht, Doohyun Kim, Yu Bai, Simon Van Mulders, Tatiana Pieloni, Nathalie Sophie Adeline Serra, Shourya Dutta Gupta, Juan Federico Esteban Müller, Philippe Schwaller, Xabier Sarasola Martin, Andrea Wulzer, Florian Patrick Marie Daniel De la Barre De Nanteuil, Rahul Kumar Gupta, Xavier Buffat, Michele Cascella, Fabio Avino, Andrey Denisov, Nicolas Andreini, Michael Schenk, Benedikt Moser, Anatole von Lilienfeld, Lorena Gonçalves de Alcântara e Freitas Krikler, Alexej Grudiev, José Luis Abelleira Fernández, Rafael Amorim Leandro De Castro Amoedo, Mukesh Kumar Tripathi, Francesco Cerutti, Sondre Vik Furuseth, Roberto Franceschini, Marco Drewes, Dragos-Adrian Seredinschi, Giovanni Migliorati, Vincenzo D'Auria, Ting-Yu Lee, Leonid Kahle, Luca Vecchi, Javier Barranco Garcia, Shang-Jung Wu, Guang Li, Alban Sublet, Darius Constantin Merk, Roberto Contino, Claudia Tambasco, Delio Aleardo Vicini, Xingyu Wu, Pablo Marcelo Perez Garcia, Jairo Camilo Quijano Perez, Andrea Thamm, Georgi Gorine, Jun Gu, Candice Megan T Young, Wanderson Oliveira Da Silva, Bernhard Auchmann, Léon Van Riesen-Haupt, Marc-Olivier Sauvain, Leonid Rivkin, Alexandra Sarabando de Carvalho, Soumya Banerjee, Agnieszka Chmielinska, Kim-Manuel Klein, Amirhossein Saba Shirvan, Craig Nowell, Peter Michael Vogel, Eva Maria Rodriguez Franco, José Luis Rivera Gutiérrez, Florent Philippe Maurice Duval, Lotta Maria Mether, Özdemir Can Kara, Franco Moretti, Charlotte Lorin, Sandra Aumon, Karin Irmgard Löw, Lucia Jimenez Rojo, Arturo Rivetti, Maria Rosaria Antonelli, Maximilian Nikolaus Bauer

We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, ...

2019

Materials engineering for immunomodulation

Jeffrey Alan Hubbell, Melody Swartz

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intrace ...

2009

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Jeffrey Alan Hubbell, Chiara Cianciaruso, Edward Allen Phelps, Steinunn Baekkeskov Hanahan

Pancreatic islet β-cells are particularly susceptible to endoplasmic reticulum (ER) stress, which is implicated in β-cell dysfunction and loss during the pathogenesis of type 1 diabetes (T1D). The peripheral membrane protein GAD65 is an autoantigen in huma ...

Amer Diabetes Assoc2016