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Caroline Vandevyver

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Related publications (44)

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A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Steve Comby, Bo Song

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

Screening of a Human Antibody Phage Display Library Against a Peptide Antigen Using Stimuli-Responsive Bioconjugates

Caroline Vandevyver

A synthetic antibody phage library, (ETH-2) was screened against the MUC-1 peptide. Two standard methods were used, namely screening on immunotubes coated with the peptide antigen and on streptavidin-coated paramagnetic particles together with a biotinylat ...

2008

Pumping of mammalian cells with a nozzle-diffuser micropump

Martinus Adela Maria Gijs, Horst Arthur Vogel, Caroline Vandevyver, Christophe Yamahata, Frédéric Lacharme, Paulina Izewska

We discuss the successful transport of jurkat cells and 5D10 hybridoma cells using a reciprocating micropump with nozzle-diffuser elements. The effect of the pumping action on cell viability and proliferation, as well as on the damaging of cellular membran ...

Royal Society of Chemistry2005

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

Martinus Adela Maria Gijs, Virendra Kumar Parashar, Caroline Vandevyver, Ulrike Lehmann

Miniaturized system for bioanalysis have been constantly gaining importance and interest within the recent years. The reduction of sample consumption and reaction time are some of the major advantages of such lab-on-a-chip applications. One of the greatest ...

2007

Synthesis and cell localization of self-assembled dinuclear lanthanide bioprobes

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. In this paper, we expa ...

Royal Society, The2013

Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

Martinus Adela Maria Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hans-Anton Lehr

PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes. ...

2009

On-chip antibody handling and detection in a magnetic droplet manipulation system

Martinus Adela Maria Gijs, Virendra Kumar Parashar, Caroline Vandevyver, Ulrike Lehmann

2006

Active microfluidic mixer using virtual source-sink pairs for DNA purification

Martinus Adela Maria Gijs, Caroline Vandevyver, Hüseyin Cumhur Tekin

We present an active mixer based on the creation of virtual source-sink pairs in a polydimethylsiloxane (PDMS) chip. Perfect mixing is achieved in only a sub-second time interval for a compact 5 μL mixing volume. This excellent performance is achieved than ...

2010

Micropatterning of protein-functionalized magnetic beads on glass using electrostatic self-assembly

Martinus Adela Maria Gijs, Abdeljalil Sayah, Caroline Vandevyver, Venkataragavalu Sivagnanam

We demonstrate a simple and fast method for self-assembly-driven micropatterning of protein functionalized magnetic beads on glass. We use positively charged aminosilane micro-patterns as template for selective immobilization of streptavidin-coated beads b ...

Elsevier2008

Droplet-Based DNA Purification in a Magnetic Lab-on-a-Chip

Martinus Adela Maria Gijs, Virendra Kumar Parashar, Caroline Vandevyver, Ulrike Lehmann

Merge, Mix, Split and Transport, these are the main manipulation steps used for on-chip droplet-based DNA purification (see figure). The system is able to extract genomic material from dilute cell samples by using the actuation of magnetic microparticles w ...

Wiley-VCH Verlag GmbH2006

Caroline Vandevyver

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A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Screening of a Human Antibody Phage Display Library Against a Peptide Antigen Using Stimuli-Responsive Bioconjugates

Pumping of mammalian cells with a nozzle-diffuser micropump

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

Synthesis and cell localization of self-assembled dinuclear lanthanide bioprobes

Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

On-chip antibody handling and detection in a magnetic droplet manipulation system

Active microfluidic mixer using virtual source-sink pairs for DNA purification

Micropatterning of protein-functionalized magnetic beads on glass using electrostatic self-assembly

Droplet-Based DNA Purification in a Magnetic Lab-on-a-Chip

Droplets and DNA: Extracting and Purifying DNA in a Magnetic Droplet Manipulation System

Time-Resolved Luminescence for Immunohistochemical Detection of Cancer Biomarkers in a Lab-on-a-Chip

A Lab-on-a-Chip using magnetic droplets

Micropatterning of Streptavidin-Functionalized Magnetic Beads on Glass Using Electrostatic Self-Assembly

Magnetic bead retention device for full on-chip sandwich immuno-assay

On-chip nanoliter immunoassay by geometrical trapping of magnetic nanoparticle chains

Magnetic on-chip DNA Extraction in a Droplet-Based Microsystem

Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices

A magnetic droplet-based Lab-on-a-Chip