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Caroline Vandevyver

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Related publications (44)

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand 6,6’- [methylenebis(1-methyl-1H-benzimid- azole-5,2-diyl)]bis(4-{2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy}pyridine-2-carboxylic acid) (H2LC2) has been tailored to self-assemble with lanthanide ions (LnIII), which results in the formatio ...

2008

Magnetic bead retention device for full on-chip sandwich immuno-assay

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme

2008

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

On-chip nanoliter immunoassay by geometrical trapping of magnetic nanoparticle chains

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme

2008

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Martinus Gijs, Caroline Vandevyver, Virendra Kumar Parashar, Ulrike Lehmann

We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles con ...

2007

Micropatterning of Streptavidin-Functionalized Magnetic Beads on Glass Using Electrostatic Self-Assembly

Abdeljalil Sayah, Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam

2007

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

Martinus Gijs, Caroline Vandevyver, Virendra Kumar Parashar, Damien de Courten, Ulrike Lehmann

Miniaturized system for bioanalysis have been constantly gaining importance and interest within the recent years. The reduction of sample consumption and reaction time are some of the major advantages of such lab-on-a-chip applications. One of the greatest ...

2007

New Opportunities for Lanthanide Luminescence

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin

Trivalent lanthanide ions display fascinating optical properties. The discovery of the corresponding elements and their fist industrial uses were intimately linked to their optical properties. This relationship has been kept alive until today when many hig ...

2007

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin

A new macrocyclic ligand,

L^3

, has been synthesised, based on the cyclen framework grafted with three phenacyl light-harvesting groups and a C5-alkyl chain bearing a carboxylic acid function as a potential linker for biological material. Acidity constant ...

2007

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin

Water-soluble triple-stranded [Ln2(L)3] helicates have been successfully tested as imaging probes in human cervical adenocarcinoma cells (HeLa), the complex being not toxic and clearly staining their cytoplasm in a concentrationdependent manner. ...

Royal Society of Chemistry2007

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby

A new polydentate tripodal ligand T2soxMe was synthesized to take advantage of the chelating effect of tridentate 8- hydroxyquinolinate subunits. Potentiometric and spectrophotometric titrations reveal seven pKa values of between 3.7 and 10.2. In water, th ...

2007

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Caroline Vandevyver

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Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Magnetic bead retention device for full on-chip sandwich immuno-assay

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

On-chip nanoliter immunoassay by geometrical trapping of magnetic nanoparticle chains

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Micropatterning of Streptavidin-Functionalized Magnetic Beads on Glass Using Electrostatic Self-Assembly

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

New Opportunities for Lanthanide Luminescence

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Magnetic particles as mobile substrates on biochips

A magnetic droplet-based Lab-on-a-Chip

A Lab-on-a-Chip using magnetic droplets

Microfluidic system for analytical applications : a magnetic droplet-based Lab-on-a-Chip

DNA capture and elution in a magnetic droplet manipulation system

Droplets and DNA: Extracting and Purifying DNA in a Magnetic Droplet Manipulation System

On-chip antibody handling and detection in a magnetic droplet manipulation system