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Geoffrey Bodenhausen

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Related publications (143)

A spinning thermometer to monitor microwave heating and glass transitions in dynamic nuclear polarization

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Pascal Miéville, Marc Anthony Caporini

As previously demonstrated by Thurber and Tycko, the peak position of Br-79 in potassium bromide (KBr) allows one to determine the temperature of a spinning sample. We propose to adapt the original design by using a compact KBr tablet placed at the bottom ...

Wiley-Blackwell2011

Three-field NMR to preserve hyperpolarized proton magnetization as long-lived states in moderate magnetic fields

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

This communication describes a three-field experiment where inequivalent scalar coupled spin pairs are hyperpolarized at 3.35 T and 1.2 K by dynamic nuclear polarization (DNP), rapidly transferred to high field (7 T) to prepare a suitable initial condition ...

Elsevier2011

Method for nmr spectrometry or mri measurement using dissolution dynamic nuclear polarization (dnp) with scavenging of free radicals

Geoffrey Bodenhausen, Sami Jannin, Pascal Miéville

PROBLEM TO BE SOLVED: To provide a method for extending longitudinal relaxation time and transverse relaxation time in nuclear magnetic resonance (NMR), while removing free radicals from hyperpolarized solution. SOLUTION: A method for preparing samples for ...

2011

Long-Lived States to Monitor Protein Unfolding by Proton NMR

Geoffrey Bodenhausen, Riddhiman Sarkar, Aurélien Bornet, Paul Romeo Vasos, Puneet Ahuja

The relaxation of long-lived states (LLS) corresponds to the slow return to statistical thermal equilibrium between symmetric and antisymmetric proton spin states. This process is remarkably sensitive to the presence of external spins and can be used to ob ...

Wiley-Blackwell2011

Fractional Spin-Labeling of Polymers for Enhancing NMR Sensitivity by Solvent-Free Dynamic Nuclear Polarization

Andrzej Sienkiewicz, Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Françoise Borcard, Pascal Miéville, Marc Anthony Caporini

Wiley-Blackwell2011

Reflections of pathways: A short perspective on ‘Selection of coherence transfer pathways in NMR pulse experiments’

Geoffrey Bodenhausen

Academic Press Inc - Elsevier Science2011

Quenching homonuclear couplings in magnetic resonance by trains of non-refocusing pulses

Geoffrey Bodenhausen

Trains of 2pi or 4pi pulses fail to refocus offsets but can suppress the effects of bilinear interactions such as homonuclear scalar couplings. ...

Academic Press Inc - Elsevier Science2011

Hyperpolarizing Gases via Dynamic Nuclear Polarization and Sublimation

Arnaud Comment, Jean-Philippe Ansermet, Geoffrey Bodenhausen, François Lazeyras, Rolf Gruetter, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja, Pascal Miéville, Jean-Noël Hyacinthe

A high throughput method was designed to produce hyperpolarized gases by combining lowtemperature dynamic nuclear polarization with a sublimation procedure. It is illustrated by applications to 129Xe nuclear magnetic resonance in xenon gas, leading to a si ...

American Physical Society2010

Bibliometrics as Weapons of Mass Citation - La bibliométrie comme arme de citation massive

Geoffrey Bodenhausen

The allocation of resources for research is increasingly based on so-called ‘bibliometrics’. Scientists arenow deemed to be successful on the sole condition that their work be abundantly cited. This world-wide trendappears to enjoy support not only by gran ...

Schweizerische Chemische Gesellschaft2010

Kinetics of Yttrium-Ligand Complexation Monitored Using Hyperpolarized 89Y as a Model for Gadolinium in Contrast Agents

Geoffrey Bodenhausen, Lothar Helm, Sami Jannin, Pascal Miéville

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) enhances Y-89 spin magnetization by 3 to 4 orders of magnitude and provides a way to monitor yttrium-ligand complexation "on the fly" by means of Y-89 NMR. In this communication, we show a ...

American Chemical Society2010

Scavenging Free Radicals To Preserve Enhancement and Extend Relaxation Times in NMR using Dynamic Nuclear Polarization

Arnaud Comment, Geoffrey Bodenhausen, Sandrine Gerber, Rolf Gruetter, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja, Pascal Miéville, Mor-Miri Mishkovsky

Vitamin C for longer lifetimes: N-oxide radicals that are widely used for dynamic nuclear polarization can be reduced by scavengers such as sodium ascorbate (vitamin C) during the dissolution process, thus diminishing losses of polarization during the tran ...

Wiley-Blackwell2010

Preservation of heteronuclear multiple-quantum coherences in NMR by double-resonance irradiation

Geoffrey Bodenhausen, Mariachiara Verde, Simone Ulzega, Fabien Ferrage

A heteronuclear double-resonance (HDR) method based on MLEV-32 or WALTZ-32 pulse sequences has been designed for the investigation of relaxation of heteronuclear multiple-quantum (MQ) coherences. The theoretical analysis of this technique uses average Hami ...

2009

Diffusion Coefficients of Biomolecules Using Long-Lived Spin States

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

We report the first observation of long-lived states (LLS) having lifetimes TLLS that exceed the corresponding spin−lattice relaxation times T1 by more than a factor 6 in a protein. Slow diffusion coefficients characteristic of large biomolecules can be de ...

2009

Long-lived states to sustain hyperpolarized magnetization

Arnaud Comment, Jean-Philippe Ansermet, Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reserv ...

National Academy of Sciences2009

Proton NMR of15N-choline metabolites enhanced by dynamic nuclear polarization

Arnaud Comment, Geoffrey Bodenhausen, Rolf Gruetter, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

(Figure Presented) Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperp ...

2009

Long-lived States in Multiple-Spin Systems

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

Long-lived spin states are excited in molecules featuring more than two isolated coupled spins, including amino acids. The figure shows the exponential recovery with the longest time-constant in aspartic acid, T1max=5.842±0.004 s, and of the decay of the l ...

2009

Heteronuclear Double Resonance in NMR Spectroscopy: Relaxation of Multiple Quantum Coherences

Geoffrey Bodenhausen, Mariachiara Verde, Simone Ulzega, Fabien Ferrage

Theoretical and experimental investigations of the relaxation rates of multiple-quantum coherences during heteronuclear double resonance (HDR) pulse sequences are presented. Average Liouvillian theory yields analytical expressions to describe the effective ...

2009

Singlet-state exchange NMR spectroscopy for the study of very slow dynamic processes

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos

Solution-state nuclear magnetic resonance method for singlet-state nuclear magnetic resonance-spectroscopy, involves performing transformation of zero-quantum coherences into singlet-state populations by radio frequency irradiation ...

2009

Apparent Transverse Relaxation Rates in Systems with Scalar-Coupled Protons

Geoffrey Bodenhausen

The modulation of spin echoes by homonuclear scalar couplings render the determination of transverse relaxation rates of individual spins difficult, in particular for molecules that are isotopically enriched in 13C or 15N, and for all molecules with scalar ...

2009

Cross-encoded magnetic resonance imaging in inhomogeneous fields

Geoffrey Bodenhausen

In magnetic resonance imaging (MRI), it is possible to cancel the effects of severe inhomogeneities of the magnetic field even if the field profile is unknown. The new ‘cross-encoded’ method is based on adiabatic frequency-modulated pulses combined with tw ...

Academic Press Inc - Elsevier Science2009

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