Publications by Harald Van Lintel

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Previous studies provide strong evidence for the therapeutic effect of electromagnetic fields (EMFs) on different tissues including cartilage. Diverse exposure parameters applied in scientific reports and the unknown interacting mechanism of EMF with biolo ...

We report an alternative technique to perform a direct and local measurement of electrical resistivities in a layered retinal tissue. Information on resistivity changes along the depth in a retina is important for modelling retinal stimulation by retinal prostheses. Existing techniques for resistivity-depth profiling have the drawbacks of a complicated experimental setup, a less localised resistivity probing and/or lower stability for measurements. We employed a flexible microprobe to measure local resistiv

The ability to control and pump high ionic strength fluids inside microchannels forms a major advantage for clinical diagnostics and drug screening processes, where high conductive biological and physiological buffers are used. Despite the known potential ...

A description of ion transport through geometrically defined nanoslits is presented. It is characterized by the effective surface charge density and was obtained by impedance spectroscopy measurements of electrolytes with different physico-chemical propert ...

Combining bacterial bioreporters with microfluidics systems holds great promise for in-field detection of chemical or toxicity targets. Recently we showed how Escherichia coli cells engineered to produce a variant of green fluorescent protein after contact ...

New cell-imprint surface modification techniques based on direct-cell photolithography and optical soft lithography using poly(dimethylsiloxane) (PDMS) cell imprints are presented for enhanced cell-based studies. The core concept of engineering materials f ...

We develop a microionizer as the ion source in a miniaturized spectrometerlike gas analyzer, operating at atmospheric pressure. Several options for the ionizing principle were considered. The application of dc glow discharge in a microsystem was studied in ...

A set of new technologies to fabricate microchannels using photosensitive polymer materials is presented. They are based on the use of polymers, hereafter called photopolymers, that are cured with UV light under a mask exposure. The basic material is ail epoxy-based photopolymer which can be patterned in thick layers with high aspect ratio.-Several process variations for making multilayered channel network are described and discussed. a) a process based on the refill of channels with a non-sensitive polymer

We present a compact portable biosensor to measure arsenic As(III) concentrations in water using Escherichia coli bioreporter cells. Escherichia coli expresses green fluorescent protein in a linearly dependent manner as a function of the arsenic concentrat ...

This paper presents a remotely powered implantable heart monitoring system for freely moving animals. The system measures the blood pressure in the left ventricle of the heart and transmits the data to a database unit. The implanted unit is remotely powere ...

This paper describes the development of a polyimide/SU-8 catheter-tip MEMS gauge pressure sensor. Finite element analysis was used to investigate critical parameters, impacting on the device design and sensing characteristics. The sensing element of the device was fabricated by polyimide-based micromachining on a flexible membrane, using embedded thin-film metallic wires as piezoresistive elements. A chamber containing this flexible membrane was sealed using an adapted SU-8 bonding technique. The device was

For the development of micro gas sensors, studies of field ionization and break-down in small gaps were performed. A finite element simulation was done for an estimate of the achievable field strength near a nanotube tip in small gaps. The simulation also ...

Within the overall objective of developing a low dead volume technology for basic microfluidic valving, shunting and switching functionalities, the use of microbubbles is proposed. As a case study, a normally-closed, bubble-based microvalve design is presented. The valve, implemented using an all-Pyrex technology, can withstand high pressures limited only by the degree to which the vertical etch rate of Pyrex can be controlled. Measurements made on several prototypes show valve breaking pressures of approxi

Using the concept of insulator-based "electrodeless" dielectrophoresis, we present a novel geometry for shaping electric fields to achieve lateral deviation of particles in liquid flows. The field is generated by lateral planar metal electrodes and is guid ...

Contamination with arsenic is a recurring problem in both industrialized and developing countries. Drinking water supplies for large populations can have concentrations much higher than the permissible levels (for most European countries and the United Sta ...

Living bacteria or yeast cells are frequently used as bioreporters for the detection of specific chemical analytes or conditions of sample toxicity. In particular, bacteria or yeast equipped with synthetic gene circuitry that allows the production of a rel ...

We present a microfluidic platform allowing dielectrophoresis-assisted formation of cell aggregates of controlled size and composition under flow conditions. When specific ex- perimental conditions are met, negative dielectrophoresis allows efficient conce ...

We present the fabrication and evaluation of microdebubblers that are able to remove large bubbles while keeping a very low dead volume. The devices use a polytetrafluoroethylene membrane that is permeable to air in order to filter air bubbles out of an aqueous sample. The dead volume of the devices is less than one microliter, but bubbles as large as 60 microliters can be removed. This simple solution can be very useful for microfluidic devices for chemical or biological analysis that suffer from channel c

In the rod and hole paradox as described by Rindler (1961 Am. J. Phys. 29 365–6) ('length contraction paradox'), a rigid rod moves at high speed over a table towards a hole of the same size. A bystander expects the rod to fall into the hole, but a co-movin ...

Ca2+ plays a crucial role in cell communication. For example, periodical changes in Ca2+ concentration act as cell sig- nals. Intracellular Ca2+ signals have been measured by Ca2+ sensitive fluorescent dye [1]. In this study, extracellular Ca2+ variation w ...

Harald Van Lintel

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Efficacy of pulsed electromagnetic fields and electromagnetic fields tuned to the ion cyclotron resonance frequency of Ca2+ on chondrogenic differentiation

Direct localised measurement of electrical resistivity profile in rat and embryonic chick retinas using a microprobe

Bi-directional AC electrothermal micropump for on-chip biological applications

Effect of the surface charge on ion transport through nanoslits

Miniaturized bacterial biosensor system for arsenic detection holds great promise for making integrated measurement device

Cell-Imprint Surface Modification by Contact Photolithography-Based Approaches: Direct-Cell Photolithography and Optical Soft Lithography Using PDMS Cell Imprints

Study of micro-glow discharges as ion sources for ion mobility spectrometry

Photo-polymer microchannel technologies and applications

Compact portable biosensor for arsenic detection in aqueous samples with Escherichia coli bioreporter cells

Remotely powered implantable heart monitoring system for freely moving animals

Polyimide/SU-8 catheter-tip MEMS gauge pressure sensor

Study of gas ionization schemes for micro devices

Bubble engineering for biomedical valving applications

Characterization and optimization of liquid electrodes for lateral dielectrophoresis

Development of a microfluidics biosensor for agarose-bead immobilized Escherichia coli bioreporter cells for arsenite detection in aqueous samples

An automated microreactor for semi-continuous biosensor measurements

Dielectrophoresis‐assisted creation of cell aggregates under flow conditions using planar electrodes

High-Throughput Micro-Debubblers for Bubble Removal with Sub-Microliter Dead Volume

The rod and hole paradox re-examined

A Ca2+ ion selective electrode biosensor in microfluidics to monitor hepatocyte’s activities