Publication

Bubble engineering for biomedical valving applications

Philippe Renaud, Harald Van Lintel, Yit-Shun Leung Ki
2000
Conference Papers

Abstract

Within the overall objective of developing a low dead volume technology for basic microfluidic valving, shunting and switching functionalities, the use of microbubbles is proposed. As a case study, a normally-closed, bubble-based microvalve design is presented. The valve, implemented using an all-Pyrex technology, can withstand high pressures limited only by the degree to which the vertical etch rate of Pyrex can be controlled. Measurements made on several prototypes show valve breaking pressures of approximately 180 Kpa (gage) which closely match theoretically predicted values. A geometry-based trap is used to form bubbles of air with long persistence times (> 24 hours). Presentation of the microvalve is followed by a general discussion of design and engineering issues surrounding the control and creation of microbubbles for microfluidic applications. Issues Include bubble pinning at sharp transitions and inclusions, and actuation.

Official source

https://infoscience.epfl.ch/entities/publication/ec834cba-9f39-4768-beca-73da4c03282b

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Philippe Renaud, Harald Van Lintel, Yit-Shun Leung Ki
2000
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ec834cba-9f39-4768-beca-73da4c03282b

About this result

Related concepts (28)

Microfluidics

Microfluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.

Droplet-based microfluidics

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Related publications (1)

Bubble engineering for biomedical valving applications

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