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Daniel Sage

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Related publications (72)

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Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Jelle Tymen Christiaan Schrauwen, Michaël Unser, Nikolaos Stergiopoulos, Alessandra Griffa, Daniel Sage, Aristotelis Agianniotis

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Flow Measurements in Sewer Systems Based on Image Analysis: Automatic Flow Velocity Algorithm

David Andrew Barry, Luca Rossi, Daniel Sage, Salim Kayal

Discharges of combined sewer overflows (CSOs) and stormwater are recognized as an important source of environmental contamination. However, the harsh sewer environment and particular hydraulic conditions during rain events reduce the reliability of traditi ...

GRAIE2010

Closed-Form Expression of the Fourier Ring-Correlation for Single-Molecule Localization Microscopy

Michaël Unser, Daniel Sage, Emmanuel Emilien Louis Soubies, Thanh-An Michel Pham

Single-molecule localization microscopy (SMLM) is a popular microscopic technique that achieves super resolution imaging by localizing individual blinking molecules in thousands of frames. Therefore, the reconstructed high-resolution image is a combination ...

IEEE2019

Effect of aging on elastin functionality in human cerebral arteries

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Jean Fasel

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...

ASA2009

Parametric Experimental Study and Design of Experiment Modelling of Sapphire Grinding

Daniel Sage

This study investigates and models the grinding process of single crystal sapphire. Five parameters: the wheel speed, the feed speed, the vertical feed, the ultrasonic assistance and the crystallographic direction were considered via a design of experiment ...

Elsevier2017

Steer'n'Detect: fast 2D template detection with accurate orientation estimation

Michaël Unser, Daniel Sage, Julien René Fageot, Zsuzsanna Püspöki

Motivation: Rotated template matching is an efficient and versatile algorithm to analyze microscopy images, as it automates the detection of stereotypical structures, such as organelles that can appear at any orientation. Its performance however quickly de ...

Oxford University Press2022

Advanced Image Processing for Biology, and the Open Bio Image Alliance (OBIA)

Michaël Unser, Daniel Sage, Ricard Delgado Gonzalo

The field of biological imaging has evolved considerably during the past decade as a result of recent (r)evolutions in fluorescence labeling and optical microscopy. Bioimage informatics has been identified as a top priority to cope with the ever-increasing ...

EUSIPCO2013

Pocket guide to solve inverse problems with GlobalBioIm

Michaël Unser, Daniel Sage, Michael Thompson McCann, Emmanuel Emilien Louis Soubies, Thanh-An Michel Pham, Laurène Donati, Thomas Jean Debarre, Ferréol Arnaud Marie Soulez

GlobalBioIm is an open-source MATLAB (R) library for solving inverse problems. The library capitalizes on the strong commonalities between forward models to standardize the resolution of a wide range of imaging inverse problems. Endowed with an operator-al ...

2019

Surpassing light inhomogeneities in structured-illumination microscopy with FlexSIM

Michaël Unser, Daniel Sage

Super-resolution structured-illumination microscopy (SIM) is a powerful technique that allows one to surpass the diffraction limit by up to a factor two. Yet, its practical use is hampered by its sensitivity to imaging conditions which makes it prone to re ...

2024

Controlled Exchange of Chromosomal Arms Reveals Principles Driving Telomere Interactions in Yeast

Michaël Unser, Daniel Sage

The 32 telomeres in the budding yeast genome cluster in three to seven perinuclear foci. Although individual telomeres and telomeric foci are in constant motion, preferential juxtaposition of some telomeres has been scored. To examine the principles that g ...

Cold Spring Harbor Laboratory Press2008

Optimal-Transport-Based Metric for SMLM

Michaël Unser, Daniel Sage, Thanh-An Michel Pham, Pol del Aguila Pla, Quentin Alain Denoyelle

We propose the use of Flat Metric to assess the performance of reconstruction methods for single-molecule localization microscopy (SMLM) in scenarios where the ground-truth is available. Flat Metric is intimately related to the concept of optimal transport ...

IEEE2021

Potential of Ultraviolet Wide-Field Imaging and Multiphoton Microscopy for Analysis of Dehydroergosterol in Cellular Membranes

Daniel Sage

Dehydroergosterol (DHE) is an intrinsically fluorescent sterol with absorption/emission in the ultraviolet (UV) region and biophysical properties similar to those of cholesterol. We compared the potential of UV-sensitive low-light-level wide-field (UV-WF) ...

Wiley2011

Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features

Michaël Unser, Cathrin Brisken, Daniel Sage, Olivier Burri, Martin Weigert, Fabio De Martino

Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal breast epithelium. However, data analysis gener ...

2021

Flow measurements in sewer systems based on image analysis: automatic flow velocity algorithm

David Andrew Barry, Luca Rossi, Daniel Sage, Laurent Son Nguyen, Salim Kayal

GRAIE2010

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Michaël Unser, Christophe Bauer, Daniel Sage

Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...

Springer2013

Vision-Based System for the Control and Measurement of Wastewater Flow Rate in Sewer Systems

David Andrew Barry, Michaël Unser, Luca Rossi, Daniel Sage, Salim Kayal

IWA2009

A framework for evaluating the performance of SMLM cluster analysis algorithms

Daniel Sage, Juliette Griffie

This analysis compares the performance of seven algorithms for cluster analysis of single-molecule localization microscopy data. The results provide a framework for comparing these types of methods and point users to the best tools. ...

Nature Publishing Group2023

Circadian gene expression is resilient to large fluctuations in overall transcription rates

Thomas d'Eysmond, Michaël Unser, Daniel Sage, Felix Naef

Mammalian circadian oscillators are considered to rely on transcription/translation feedback loops in clock gene expression. The major and essential loop involves the autorepression of cryptochrome (Cry1, Cry2) and period (Per1, Per2) genes. The rhythm-gen ...

Nature Publishing Group2009

Deforming Tessellations for the Segmentation of Cell Aggregates

Michaël Unser, Daniel Sage, Aymeric Alexandre Galan, Anaïs Laure Marie-Thérèse Badoual

We present a new active contour to segment cell aggregates. We describe it by a smooth tessellation that is attracted toward the cell membranes. Our approach relies on subdivision schemes that are tightly linked to the theory of wavelets. The shape is enco ...

IEEE2019

Bi-Exponential Edge-Preserving Smoother

Michaël Unser, Philippe Thévenaz, Daniel Sage

Edge-preserving smoothers need not be taxed by a severe computational cost. We present, in this paper, a lean algorithm that is inspired by the bi-exponential filter and preserves its structure-a pair of one-tap recursions. By a careful but simple local ad ...

Institute of Electrical and Electronics Engineers2012