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Daniel Sage

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Publications associées (72)

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Nikolaos Stergiopoulos, Michaël Unser, Daniel Sage, Alessandra Griffa, Aristotelis Agianniotis, Jelle Tymen Christiaan Schrauwen

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation

Daniel Sage

Background: Fluorescence loss in photobleaching (FLIP) is a widely used imaging technique, which provides information about protein dynamics in various cellular regions. In FLIP, a small cellular region is repeatedly illuminated by an intense laser pulse, ...

Biomed Central Ltd2012

Predicting stem cell fate changes by differential cell cycle progression patterns

Matthias Lütolf, Daniel Sage, Daniel Andreas Schmitter, Yuya Okawa, Marlen Knobloch

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systemati ...

Company of Biologists2012

A Psf-Based Approach To Biplane Calibration In 3D Super-Resolution Microscopy

Michaël Unser, Daniel Sage, Suliana Manley, Hagay Kirshner, Thomas Pengo

Super-resolution localization microscopy methods such as PALM and STORM have been shown to provide imaging with resolutions up to a few tens of nanometers while using relatively simple setups. Biplane PALM has extended the PALM technique to three-dimension ...

Ieee2012

Potential of Ultraviolet Wide-Field Imaging and Multiphoton Microscopy for Analysis of Dehydroergosterol in Cellular Membranes

Daniel Sage

Dehydroergosterol (DHE) is an intrinsically fluorescent sterol with absorption/emission in the ultraviolet (UV) region and biophysical properties similar to those of cholesterol. We compared the potential of UV-sensitive low-light-level wide-field (UV-WF) ...

Wiley2011

Flow measurements in sewer systems based on image analysis: automatic flow velocity algorithm

Luca Rossi, Daniel Sage, Laurent Son Nguyen, Salim Kayal, David Jeanbourquin, David Andrew Barry

Discharges of combined sewer overflows (CSOs) and stormwater are recognized as an important source of environmental contamination. However, the harsh sewer environment and particular hydraulic conditions during rain events reduce the reliability of traditi ...

IWA Publishing2011

Fast O(1) Bilateral Filtering Using Trigonometric Range Kernels

Michaël Unser, Daniel Sage, Kunal Narayan Chaudhury

It is well known that spatial averaging can be realized (in space or frequency domain) using algorithms whose complexity does not scale with the size or shape of the filter. These fast algorithms are generally referred to as constant-time or O(1) algorithm ...

IEEE2011

Flow measurements in sewer systems based on image analysis: automatic flow velocity algorithm

Luca Rossi, Daniel Sage, Laurent Son Nguyen, Salim Kayal, David Jeanbourquin, David Andrew Barry

GRAIE2010

Fast Detection of Cells Using a Continuously Scalable Mexican-Hat-Like Template

Michaël Unser, Daniel Sage, Kunal Narayan Chaudhury, Zsuzsanna Püspöki

We propose a fast algorithm for the detection of cells in fluorescence images. The algorithm, which estimates the number of cells and their respective centers and radii, relies on the fast computation of intensity-based correlations between the cells and a ...

IEEE2010

Low-Bond Axisymmetric Drop Shape Analysis for Surface Tension and Contact Angle Measurements of Sessile Drops

Michaël Unser, Daniel Sage, Thierry Blu, Michael Müller

A new method based on the Young-Laplace equation for measuring contact angles and surface tensions is presented. In this approach, a first-order perturbation technique helps to analytically solve the Young-Laplace equation according to photographic images ...

Elsevier2010

Comparison of Deconvolution Software in 3D Microscopy: A User Point of View—Part 1

Daniel Sage, Alessandra Griffa

Deconvolution is an image restoration technique which improves image contrast, resolution and signal to noise ratio. In modern optical microscopy and biological research deconvolution is becoming a fundamental processing step which allows for better image ...

EMS2010

Comparison of Deconvolution Software: A User Point of View—Part 2

Daniel Sage, Alessandra Griffa

Deconvolution is an image processing technique that restores the effective object representation [3] [4], allowing to improve images analysis steps such as segmentation [1] or colocalization study [2]. We performed several deconvolution tests on different ...

EMS2010

Multicolor Bleach-Rate Imaging Enlightens in vivo Sterol Transport

Daniel Sage

Elucidation of in vivo cholesterol transport and its aberrations in cardiovascular diseases requires suitable model organisms and the development of appropriate monitoring technology. We recently presented a new approach to visualize transport of the intri ...

Landes Bioscience2010

Flow Measurements in Sewer Systems Based on Image Analysis: Automatic Flow Velocity Algorithm

Luca Rossi, Daniel Sage, Salim Kayal, David Andrew Barry

GRAIE2010

A software solution for recording circadian oscillator features in time-lapse live cell microscopy

Michaël Unser, Daniel Sage

Background: Fluorescent and bioluminescent time-lapse microscopy approaches have been successfully used to investigate molecular mechanisms underlying the mammalian circadian oscillator at the single cell level. However, most of the available software and ...

BioMed Central Ltd.2010

Selective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation

Daniel Sage

The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans' high autofluorescence in the same spectral regio ...

Wiley InterScience2010

Effect of aging on elastin functionality in human cerebral arteries

Nikolaos Stergiopoulos, Jean Fasel, Michaël Unser, Daniel Sage, Edouard Fonck

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...

ASA2009

Multiresolution Monogenic Signal Analysis Using the Riesz-Laplace Wavelet Transform

Michaël Unser, Daniel Sage, Dimitri Nestor Alice Van De Ville

The monogenic signal is the natural 2-D counterpart of the 1-D analytic signal. We propose to transpose the concept to the wavelet domain by considering a complexified version of the Riesz transform which has the remarkable property of mapping a real-value ...

Institute of Electrical and Electronics Engineers2009

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

Patrick Aebischer, Michaël Unser, Daniel Sage, Bernard Schneider, Samareh Azeredo da Silveira Lajaunias

Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies. However, the share of this modification in the events that lead to ...

Oxford University Press2009

Circadian gene expression is resilient to large fluctuations in overall transcription rates

Felix Naef, Michaël Unser, Daniel Sage, Thomas d'Eysmond

Mammalian circadian oscillators are considered to rely on transcription/translation feedback loops in clock gene expression. The major and essential loop involves the autorepression of cryptochrome (Cry1, Cry2) and period (Per1, Per2) genes. The rhythm-gen ...

Nature Publishing Group2009

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