Publication

Effect of aging on elastin functionality in human cerebral arteries

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Edouard Fonck, Jean Fasel
2009
Journal Articles

Abstract

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral arteries, their composition, and their geometry, with particular focus on the functional alteration of elastin attributable to aging.

Official source

https://infoscience.epfl.ch/entities/publication/339124a9-9137-455d-8631-27d1b696535b

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Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Edouard Fonck, Jean Fasel
2009
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/339124a9-9137-455d-8631-27d1b696535b

About this result

Related concepts (22)

Cerebral circulation

Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. Arteries deliver oxygenated blood, glucose and other nutrients to the brain. Veins carry "used or spent" blood back to the heart, to remove carbon dioxide, lactic acid, and other metabolic products. The neurovascular unit regulates cerebral blood flow so that activated neurons can be supplied with energy in the right amount and at the right time.

Geometry

Geometry (; ) is a branch of mathematics concerned with properties of space such as the distance, shape, size, and relative position of figures. Geometry is, along with arithmetic, one of the oldest branches of mathematics. A mathematician who works in the field of geometry is called a geometer. Until the 19th century, geometry was almost exclusively devoted to Euclidean geometry, which includes the notions of point, line, plane, distance, angle, surface, and curve, as fundamental concepts.

Cerebral hemisphere

The vertebrate cerebrum (brain) is formed by two cerebral hemispheres that are separated by a groove, the longitudinal fissure. The brain can thus be described as being divided into left and right cerebral hemispheres. Each of these hemispheres has an outer layer of grey matter, the cerebral cortex, that is supported by an inner layer of white matter. In eutherian (placental) mammals, the hemispheres are linked by the corpus callosum, a very large bundle of nerve fibers.

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