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Martinus Gijs

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Related publications (370)

Rapid prototyping of micro-direct methanol fuel cells in PDMS

Martinus Gijs, Meng Shen

2009

On-chip immuno-agglutination assay with analyte capture by dynamic manipulation of superparamagnetic beads

Martinus Gijs, Yves Moser

Magnetic bead-based lab-on-a-chip systems offer significant advantages compared to more conventional systems, mainly through the possibility of controlled manipulation of the magnetic carriers on-chip. In particular, microfluidic immunoassays using functio ...

2009

Time-Resolved Luminescence for Immunohistochemical Detection of Cancer Biomarkers in a Lab-on-a-Chip

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Ata Tuna Ciftlik

2009

A fixed-volume microfluidic mixer realized using multilayer PDMS technology

Martinus Gijs, Hüseyin Cumhur Tekin

We present leakage-free valves and an efficient fixed-volume mixer fabricated using a four-layer soft lithography technique in polydimethylsiloxane (PDMS). Mixing is achieved with a 95% efficiency in a few seconds by creating circular flow patterns inside ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

Influence of Oil Type and Viscosity on Droplet Size in a Flow Focusing Microfluidic Device

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

We form water-in-oil droplets in a microfluidic channel-nozzle geometry for studying the influence of viscosity of oil and of different oil classes on the droplet size. We find that the chemical structure of oil dominates over its viscosity. Our studies ar ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hui Yang

2009

Fabrication of microfluidic mixers with varying topography in glass using the powder blasting process

Abdeljalil Sayah, Martinus Gijs, Virendra Kumar Parashar

The powder-blasting method is used to fabricate structures with a three-dimensional topography in glass using elastomeric masks. The relation between the mask opening width and the erosion depth is exploited to fabricate microstructures with varying depth ...

2009

Magnetic particle dosing, release and separation in a microfluidic chip with magnetic actuation

Thomas Lehnert, Martinus Gijs, Yves Moser, Rana Afshar Ghasemlouy

2009

High-performance active-valve micropump

Martinus Gijs, Meng Shen

2009

Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme

We use magnetic microbeads, which are magnetically self-assembled in chains in a microfluidic chip, as reaction substrates to implement two different sandwich immunoassay protocols for the detection of mouse monoclonal target antibodies. The magnetic chain ...

Springer-Verlag2009

Microparticle photometry in a CMOS microsystem combining magnetic actuation and in-situ optical detection

Martinus Gijs, Cristiano Niclass, Edoardo Charbon, Ulrike Lehmann, Emile Dupont, Stefano Pietrocola

We present a hybrid CMOS-based microfluidic system that combines magnetic actuation of microparticles with in situ optical detection using single photon avalanche diodes (SPADs). The decoupling of the principles used for actuation and sensing permits a hig ...

2008

Full on-chip nanoliter immuno-assay by geometrical magnetic trapping of nanoparticle chains

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme

We propose an original concept to perform a complete on-chip sandwich immunoassay on magnetic nanoparticles that are self-assembled in chains in a uniform magnetic field. The magnetic chains are retained over periodically enlarged cross sections of a micro ...

2008

Label-free detection of DNA with interdigitated micro-electrodes in a fluidic cell

Martinus Gijs, Daniel Berdat

We investigate the analytical performance of an interdigitated electrode sensor for the label-free detection of DNA, by monitoring the complex impedance of 5 µm wide interdigitated Pt microelectrodes on a glass substrate. We detect the hybridization of unl ...

2008

On-Chip Sandwich Immunoassay in an Integrated Magneto-Optical CMOS Microsystem

Martinus Gijs, Edoardo Charbon, Ulrike Lehmann, Emile Dupont

We report on an innovative approach to on-chip detection of single fluorescently-labeled magnetic micro-particles by means of Single Photon Avalanche Diode (SPAD) arrays. Our system enables particle separation through magnetic actuation and highly sensitiv ...

2008

Active superparamagnetic bead manipulation for immunoassays on-chip

Thomas Lehnert, Martinus Gijs, Yves Moser, Emile Dupont, Rana Afshar Ghasemlouy

2008

Micropatterning of protein-functionalized magnetic beads on glass using electrostatic self-assembly

Abdeljalil Sayah, Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam

We demonstrate a simple and fast method for self-assembly-driven micropatterning of protein functionalized magnetic beads on glass. We use positively charged aminosilane micro-patterns as template for selective immobilization of streptavidin-coated beads b ...

2008

Miniaturized PMMA ball-valve micropump with cylindrical electromagnetic actuator

Christophe Yamahata, Martinus Gijs, Meng Shen

We have fabricated and characterized a reciprocating poly(methylmetacrylate) (PMMA) ball-valve micropump actuated with a miniaturized cylindrical electromagnetic circuit. By finite element calculations, we have optimized the structure of the electromagnet ...

2008

A high-performance compact electromagnetic actuator for a PMMA ball-valve micropump

Christophe Yamahata, Martinus Gijs, Meng Shen

We present the microfabrication and characterization of a reciprocating-type poly(methylmetacrylate) (PMMA) ball-valve micropump which is actuated with a high-performance and compact electromagnetic circuit of centimeter size. We have improved by finite el ...

Institute of Physics2008

DNA sensor using interdigitated microelectrodes and micro/nanoparticles

Martinus Gijs, Daniel Berdat, Hüseyin Cumhur Tekin

2008

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