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Simultaneous washing and concentration of functionalized magnetic beads in a complex sample solution was demonstrated by applying a rotational magnetic actuation system to a microfluidic chip under continuous flow conditions. The rotation of periodically arranged small permanent magnets close to the fluidic channel carrying a magnetic bead suspension allows trapping and releasing of the beads along the fluidic channel in a periodical manner. Each trapping and releasing event resembles one washing cycle.
Christoph Merten, Leonie Kolmar, Xiaoli Ma, Hongxing Hu
Martinus Adela Maria Gijs, Thomas Lehnert