Publications by Arnaud Bertsch

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Microstereolithography is a technique that allows the manufacture of small and complex three-dimensional (3D) components in plastic material. Many of the components produced by this technique are too small and too complex to be replicated by molding and, consequently, the produced components need to have adequate mechanical or chemical characteristics to be useful. Until now, the choice of materials available in the microstereolithography process was limited to plastic, with only a few photosensitive resins

The use of solvent-free microfluidics to fine-tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self-assembly is driven by pH changes in a water environment, which increases biocompatibility ...

Background: The intranasal trigeminal system contributes to the sense of smell. Its integrity in olfactory dysfunction (OD) may be crucial for future treatments. This study assessed trigeminal sensitivity in healthy individuals and patients with OD of diff ...

We present a method to measure effective diffusion coefficients of fluorescently labeled molecules inside a nanofluidic system. Molecules with small diffusion coefficients show a larger lateral dispersion than highly diffusive species, which is counterintu ...

Microstereolithography is a 3D microfabrication technology that is fundamentally different from the techniques commonly used in cleanroom environment for the manufacturing of MEMS components. Most microfabrication techniques evolved from the microelectronics industry and often use silicon wafers as substrate or carrier material, thin films of metals deposited by evaporation or sputtering, thin layers of polymers deposited by spin coating and patterned by photolithography, chemical and plasma etching to gene

Droplet breakup is an important phenomenon in the field of microfluidics to generate daughter droplets. In this work, a novel breakup regime in the widely studied T-junction geometry is reported, where the pinch-off occurs laterally in the two outlet chann ...

In this paper a nanofluidic molecular filtration system based on soft alginate hydrogel fillings and a solid-state alumina support membrane is presented. The electrostatically controlled diffusion is characterized by partition coefficient of the hydrogel and the flux through the composite membrane for positively and negatively charged dye molecules. The partition coefficient of negatively charged fluorescein sodium molecules into the gel is 2 orders of magnitude lower in 1 mM KCl solution than that in 1 M K

Microstereolithography is a 3D microfabrication technology that is fundamentally different from the techniques commonly used in cleanroom environment for the manufacturing of microelectromechanical system (MEMS) components. Most microfabrication techniques evolved from the microelectronics industry and often use silicon wafers as substrate or carrier material, thin films of metals deposited by evaporation or sputtering, thin layers of polymers deposited by spin coating and patterned by photolithography, and

We present the use of an array of rectangular microelectrodes to discriminate between different resistivities in a thin, layered sample. Each electrode was 8 rum long and 200 nm thick. The electrode widths ranged from 20 to 500/mum. The electrodes were designed such that all pairs of consecutive electrodes had the same relative geometry, and therefore identical cell constants. A hydrogel-based tissue phantom, made by photopolymerization of 2-hydroxyethyl methacrylate (HEMA), was developed. By changing the h

We developed Al2O3/W heterogeneous nanopore arrays for field effect modulated nanofluidic diodes. They are fabricated by transferring self-organized nanopores of anodic aluminium oxide into a W thin film. The nanopores are ∼20 nm in diameter and 400 nm in ...

While interference colors have been known for a longtime, conventionalcolor filters have large spatial dimensions and cannot be used tocreate compact pixelized color pictures. Here we report a simple yetelegant interference-based method of creating microsc ...

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

This paper reports on polyimide microfluidic devices fabricated by photolithography and a layer transfer lamination technology. The microchannels are sealed by laminating an uncured polyimide film on a partially cured layer and subsequent imidization. Sele ...

This study presents the development of a 3D lipid microhelix capable of simultaneously delivering drugs with different characteristics, including water-soluble and poorly water-soluble drugs. Lipid microhelix encapsulating magnetic nanoparticles (MNPs) and ...

In this work, we present the general concept of an instrumented smart knee prosthesis for in-vivo measurement of forces and kinematics. This system can be used for early monitoring of the patient after implantation and prevent possible damage to the prosth ...

Purpose: Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). Methods: The wireless CLS is a disposable silicone soft co ...

We present a simple and easy to handle PDMS microfluidic device for neuronal cell culture studies in three-dimensional hydrogel scaffolds. The hydrogel is structured in parallel layers to reconstruct cell layers close to the natural environment. Dissociated cortical neurons of embryonic rats have been cultured in 0.5% w/v agarose including 0.2% w/v alginate. The cells formed neurite networks through neighboring cell free hydrogel layers. The cell culture showed neurite outgrowth in the microfluidic channel

IB-LIGA (Ion Beam Lithographie, Galvanoformung and Abformung) is a new technique for the 3D structuring of photoresist materials. It is a direct-write (maskless) technique that uses high energy (0.5-3.5 McV) light ions (protons or helium ions) for the irradiation of photoresist materials. At CAFI (Centre d'Analyse par Faisceau Ionique), the IB-LIGA technique has been implemented. The experimental parameters for irradiation and the subsequent development have been optimised for PMMA. The results obtained so

Differentiation of stem cells into mature cells through the use of physical approaches is of great interest. Here, we prepared smart nanoenvironments by cell-imprinted substrates based on chondrocytes, tenocytes, and semifibroblasts as templates and demons ...

A novel beam profiler based on microstructured scintillation resin is presented. The detector consists of a bundle of waveguides, featuring an active area of 30 x 30 mm2 with a fill factor of 50% and a pitch of 400 mu m. This configuration is obtained by c ...

Arnaud Bertsch

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Microfabrication of ceramic components by microstereolithography

On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics

Electrical Stimulation of Trigeminal Nerve at the Anterior Nasal Septum in Healthy Individuals and Patients With Olfactory Dysfunction

Direct Measurement of Effective Diffusion Coefficients in Nanochannels Using Steady-State Dispersion Effects

Microstereolithography

Breaking one into three: Surface-tension-driven droplet breakup in T-junctions

Composite hydrogel-loaded alumina membranes for nanofluidic molecular filtration

Microstereolithography

Resistivity probing of multi-layered tissue phantoms using microelectrodes

Field effect modulated nanofluidic diode membrane based on Al2O3/W heterogeneous nanopore arrays

Aperture-Controlled Fabrication of All-Dielectric Structural Color Pixels

Controlled Release Drug Coatings on Flexible Neural Probes

Polyimide microfluidic devices with integrated nanoporous filtration areas manufactured by micromachining and ion track technology

3D Lipid Microrobots for Simultaneous Delivery of Lipophilic and Hydrophilic Drugs

Instrumented Knee Prosthesis for Force and Kinematics Measurements

Wireless contact lens sensor for intra ocular pressure monitoring: assessment on enucleated pig eyes

Microfluidic hydrogel layers with multiple gradients to stimulate and perfuse three-dimensional neuronal cell cultures

High aspect ratio, 3D structuring of photoresist materials by ion beam LIGA

Cell-Imprinted Substrates Modulate Differentiation, Redifferentiation, and Transdifferentiation

Microstructured plastic scintillators for pencil beam profiling in proton-therapy accelerators