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Arnaud Bertsch

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Publications associées (94)

LIQUID-IN-A-MEMS: ENCAPSULATION OF LIQUID IN A MICROCAPSULE BY INKJET PRINTING

Arnaud Bertsch, Jürgen Brugger, Jongeon Park

In this work we demonstrate a new process for precisely encapsulating nanoliters of aqueous solution in a microcapsule. Microcapsules were fabricated by twophoton polymerization and subsequently filled and sealed by inkjet printing. Our new approach overco ...

2023

High precision, high throughput generation of droplets containing single cells

Philippe Renaud, Arnaud Bertsch, Jiande Zhou

The Poisson limit is a major problem for the isolation of single cells in different single-cell technologies and applications. In droplet-based single-cell assays, a scheme that is increasingly popular, the intrinsic randomness during single-cell encapsula ...

ROYAL SOC CHEMISTRY2022

Dielectrophoretic Traps for Efficient Bead and Cell Trapping and Formation of Aggregates of Controlled Size and Composition

Philippe Renaud, Arnaud Bertsch, Clémentine Sophie Sarah Lipp

We present a microfluidic dielectrophoretic-actuated system designed to trap chosen single-cell and form controlled cell aggregates. A novel method is proposed to characterize the efficiency of the dielectrophoretic trapping, considering the flow speed but ...

2022

On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid

Philippe Renaud, Arnaud Bertsch, Hilal Lashuel, Daniel Ortiz Trujillo, Laure Menin, Joan Teixidor, Salvatore Novello

Continuous fluidic sampling systems allow collection of brain biomarkers in vivo. Here, we propose a new sequential and intermittent sampling paradigm using droplets, called Droplet on Demand (DoD). It is implemented in a microfabricated neural probe and a ...

AMER CHEMICAL SOC2022

Impinging planar jets: hysteretic behaviour and origin of the self-sustained oscillations

Philippe Renaud, Arnaud Bertsch, François Gallaire, Alessandro Bongarzone

The experimental and numerical investigation presented by Bertsch et al. (Phys. Rev. Fluids, vol. 5, 2020a, p. 054202) describes the self-sustained oscillations induced by the interaction of two impinging jets in microfluidic devices. While the oscillatory ...

Cambridge University Press2021

In-flow electrochemical detection of chemicals in droplets with pyrolysed photoresist electrodes: application as a module for quantification of microsampled dopamine

Philippe Renaud, Arnaud Bertsch, Joan Teixidor, Albert René Yvon Leroy

The electrochemical quantification of analytes in droplets of PBS separated by a fluorinated phase was investigated. PDMS-fused silica chips with pyrolysed photoresist electrodes were prepared using a simple fabrication technique and used to analyze drople ...

ROYAL SOC CHEMISTRY2021

Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrations

Philippe Renaud, Arnaud Bertsch, John McKinney, Ludovic Serex, Kunal Sharma

Despite its simplicity, which makes it the most commonly used bioprinting method today, extrusion-based bioprinting suffers from its inability to reproduce the complex tissue architecture found in organs. Generally, this printing method allows for the disp ...

IOP PUBLISHING LTD2021

Planar hydrodynamic traps and buried channels for bead and cell trapping and releasing

Philippe Renaud, Arnaud Bertsch, Daniel Migliozzi, Clémentine Sophie Sarah Lipp, Jonathan Bastien Cottet

We present a novel concept for the controlled trapping and releasing of beads and cells in a PDMS microfluidic channel without obstacles present around the particle or in the channel. The trapping principle relies on a two-level microfluidic configuration: ...

ROYAL SOC CHEMISTRY2021

Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells

Philippe Renaud, Arnaud Bertsch, Georg Fantner, Benoît Xavier Emmanuel Desbiolles, Mélanie Thérèse Marie Hannebelle

Atomic force microscopy based approaches have led to remarkable advances in the field of mechanobiology. However, linking the mechanical cues to biological responses requires complementary techniques capable of recording these physiological characteristics ...

AMER CHEMICAL SOC2020

Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles, Nicolas Grégoire Maïno, Etienne de Coulon, Stephan Rohr

Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...

2020

Feedback-free microfluidic oscillator with impinging jets

Philippe Renaud, Arnaud Bertsch, François Gallaire, Margaux Catherine Marie Duchamp, Alessandro Bongarzone

The present paper describes a microfluidic oscillator based on facing impinging jets and operating in laminar flow conditions. Using appropriate microchannel configurations, pulsatile liquid flows are generated at the microscale from steady and equal inlet ...

2020

Swinging jets

Philippe Renaud, Arnaud Bertsch, François Gallaire, Eunok Yim, Alessandro Bongarzone

This paper is associated with a video winner of a 2019 American Physical Society's Division of Fluid Dynamics (DFD) Gallery of Fluid Motion Award for work presented at the DFD Gallery of Fluid Motion. The original video is available online at the Gallery o ...

2020

Ion beam etching redeposition for 3D multimaterial nanostructure manufacturing

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles

A novel fabrication method based on the local sputtering of photoresist sidewalls during ion beam etching is presented. This method allows for the manufacture of three-dimensional multimaterial nanostructures at the wafer scale in only four process steps. ...

2019

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles

Micronanotechnology-based multielectrode ar- rays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a consider ...

American Chemical Society (ACS)2019

Microfluidics: A New Layer of Control for Extrusion-Based 3D Printing

Philippe Renaud, Arnaud Bertsch, Ludovic Serex

Advances in 3D printing have enabled the use of this technology in a growing number of fields, and have started to spark the interest of biologists. Having the particularity of being cell friendly and allowing multimaterial deposition, extrusion-based 3D p ...

2018

Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

Philippe Renaud, Arnaud Bertsch, Ariane Rochat, Thomas Michael Braschler, Ludovic Serex, Amélie Barbara Hildegarde Béduer, Aleksandra Filippova

Cryogels are macroporous materials that display remarkable properties, such as high pore interconnection, large surface to volume ratio, and high mechanical stability, making them good candidates for 3D cell culture. However, shaping cryogels remains chall ...

Wiley2018

In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system

Philippe Renaud, Arnaud Bertsch, Philippe Colin, Bernard Schneider, Guillaume Cédric Yves Petitpierre, Aurélien Thomas

Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temporal resolution. Here we show a functional in v ...

Nature Publishing Group2017

Multimaterial Nanoporous Membranes Shaped through High Aspect-Ratio Sacrificial Silicon Nanostructures

Philippe Renaud, Arnaud Bertsch, Stefano Silvio Giovanni Varricchio, Niccolo Piacentini

We present an innovative fabrication method for solid-state nanoporous membranes based on the casting of sacrificial silicon nanostructures. The process allows the individual definition of geometry and placement of each nanopore through e-beam lithography ...

Amer Chemical Soc2017

Droplet extraction module for the analysis of segmented flow generated by a neural probe

Philippe Renaud, Arnaud Bertsch, Guillaume Cédric Yves Petitpierre, Colin Darbellay

We recently developed a neural probe allowing to capture at high temporal resolution nano-volume droplets of interstitial fluid from the brain organized in a segmented flow. In order to enable the analysis of these small volume and low concentration drople ...

2016

Cell-Imprinted Substrates Modulate Differentiation, Redifferentiation, and Transdifferentiation

Philippe Renaud, Arnaud Bertsch, Morteza Mahmoudi, Shahin Bonakdar, Leila Montazeri, Mojtaba Taghipoor, Omid Mashinchian

Differentiation of stem cells into mature cells through the use of physical approaches is of great interest. Here, we prepared smart nanoenvironments by cell-imprinted substrates based on chondrocytes, tenocytes, and semifibroblasts as templates and demons ...

Amer Chemical Soc2016

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