Publications by Arnaud Bertsch

Related publications (94)

Dielectric spectroscopy in a micromachined flow cytometer: theoretical and practical considerations

Philippe Renaud, Arnaud Bertsch, Shady Didier Gawad, Urban Seger, Karen Cheung

We propose a model to determine the influence of different cell properties, such as size, membrane capacitance and cytoplasm conductivity, on the impedance spectrum as measured in a microfabricated cytometer. A dielectric sphere of equivalent complex permi ...

2004

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Philippe Renaud, Arnaud Bertsch, Clémentine Sophie Sarah Lipp

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

ROYAL SOC CHEMISTRY2023

Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrations

Philippe Renaud, Arnaud Bertsch, John McKinney, Ludovic Serex, Kunal Sharma

Despite its simplicity, which makes it the most commonly used bioprinting method today, extrusion-based bioprinting suffers from its inability to reproduce the complex tissue architecture found in organs. Generally, this printing method allows for the disp ...

IOP PUBLISHING LTD2021

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

Philippe Renaud, Arnaud Bertsch, Robert Meissner, Sri Harsha Kasi Raj, Bilge Eker

We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell cont ...

2011

Simulation of epiretinal prostheses - Evaluation of geometrical factors affecting stimulation thresholds

Philippe Renaud, Arnaud Bertsch, Willyan Hasenkamp Carreira, Sri Harsha Kasi Raj, Grégoire Cosendai

Background An accurate understanding of the electrical interaction between retinal prostheses and retinal tissue is important to design effective devices. Previous studies have used modelling approaches to simulate electric fields generated by epiretinal p ...

BioMed Central2011

Facile fabrication of nanofluidic diode membranes using anodic aluminium oxide

Jürgen Brugger, Philippe Renaud, Arnaud Bertsch, Oscar Vazquez Mena, Songmei Wu, Fabien Patrick Wildhaber

Active control of ion transport plays important roles in chemical and biological analytical processes. Nanofluidic systems hold the promise for such control through electrostatic interaction between ions and channel surfaces. Most existing experiments rely ...

Royal Soc Chemistry2012

Al2O3/W hetero-structured nanopore membranes: From native to tunable nanofluidic diodes

Jürgen Brugger, Philippe Renaud, Arnaud Bertsch, Songmei Wu, Fabien Patrick Wildhaber

We present here Al2O3/W hetero-structured nanopore membranes which function as native and electrical field tunable nanofluidic diodes. A typical membrane is 100×100 μm2 in size with pore density of ∼ 20/μm2. The nanopores are 26 nm in diameter and 400 nm i ...

IEEE2013

High precision, high throughput generation of droplets containing single cells

Philippe Renaud, Arnaud Bertsch, Jiande Zhou

The Poisson limit is a major problem for the isolation of single cells in different single-cell technologies and applications. In droplet-based single-cell assays, a scheme that is increasingly popular, the intrinsic randomness during single-cell encapsula ...

ROYAL SOC CHEMISTRY2022

Temperature Sensitivity of Nanochannel Electrical Conductance

Philippe Renaud, Arnaud Bertsch, Mojtaba Taghipoor

Electrical measurement is a widely used technique for the characterization of nanofluidic devices. The electrical conductivity of electrolytes is known to be dependent on temperature. However, the similarity of the temperature sensitivity of the electrical ...

Amer Chemical Soc2015

Neural probe combining microelectrodes and a droplet-based microdialysis collection system for high temporal resolution sampling

Philippe Renaud, Arnaud Bertsch, Guillaume Cédric Yves Petitpierre

We propose a novel neural probe which combines microfluidic channels with recording and stimulation electrodes. The developed microfabrication approach enables the concentration of every active element such as electrodes and the sampling inlet in close pro ...

Royal Society of Chemistry2016

First steps toward noninvasive intraocular pressure monitoring with a sensing contact lens

Philippe Renaud, Arnaud Bertsch, Matteo Leonardi

PURPOSE. To present a novel and minimally invasive approach to intraocular pressure (IOP) monitoring based on a sensing contact lens. METHODS. The key element of this measurement method is a soft contact lens with an embedded microfabricated strain gauge a ...

2004

A microfluidic approach to synthesizing high-performance microfibers with tunable anhydrous proton conductivity

Philippe Renaud, Arnaud Bertsch, Mohammad Mahdi Hasani-Sadrabadi, Jules John Vandersarl

Here, we demonstrate a new approach for the synthesis of ion exchange microfibers with finely tuned anhydrous conductivity. This work presents microfluidics as a system to control the size and phosphoric acid (PA) doping level of the polybenzimidazole (PBI ...

Royal Society of Chemistry2013

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles

Micronanotechnology-based multielectrode ar- rays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a consider ...

American Chemical Society (ACS)2019

Partial release and detachment of microfabricated metal and polymer structures by anodic metal dissolution

Philippe Renaud, Arnaud Bertsch, Stefan Metz

The large majority of microelectromechanical systems (MEMS) are fabricated on silicon, glass or Pyrex substrates by manufacturing techniques, which originated from the semiconductors industry. However, their final application often requires removal of the ...

Institute of Electrical and Electronics Engineers2005

In-flow electrochemical detection of chemicals in droplets with pyrolysed photoresist electrodes: application as a module for quantification of microsampled dopamine

Albert René Yvon Leroy, Philippe Renaud, Arnaud Bertsch, Joan Teixidor

The electrochemical quantification of analytes in droplets of PBS separated by a fluorinated phase was investigated. PDMS-fused silica chips with pyrolysed photoresist electrodes were prepared using a simple fabrication technique and used to analyze drople ...

ROYAL SOC CHEMISTRY2021

Hot topic: Mapping of the human intranasal mucosal thermal sensitivity: A clinical study on thermal threshold and trigeminal receptors

Arnaud Bertsch, Evgenii Glushkov

Introduction The olfactory and trigeminal system are closely interlinked. Existing literature has primarily focused on characterizing trigeminal stimulation through mechanical and chemical stimulation, neglecting thermal stimulation thus far. The present s ...

2024

Impinging planar jets: hysteretic behaviour and origin of the self-sustained oscillations

Philippe Renaud, François Gallaire, Arnaud Bertsch, Alessandro Bongarzone

The experimental and numerical investigation presented by Bertsch et al. (Phys. Rev. Fluids, vol. 5, 2020a, p. 054202) describes the self-sustained oscillations induced by the interaction of two impinging jets in microfluidic devices. While the oscillatory ...

Cambridge University Press2021

On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics

Philippe Renaud, Arnaud Bertsch, Mohammad Mahdi Hasani-Sadrabadi, Jules John Vandersarl

The use of solvent-free microfluidics to fine-tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self-assembly is driven by pH changes in a water environment, which increases biocompatibility ...

Wiley-Blackwell2014

Electrical Stimulation of Trigeminal Nerve at the Anterior Nasal Septum in Healthy Individuals and Patients With Olfactory Dysfunction

Arnaud Bertsch, Clémentine Sophie Sarah Lipp

Background: The intranasal trigeminal system contributes to the sense of smell. Its integrity in olfactory dysfunction (OD) may be crucial for future treatments. This study assessed trigeminal sensitivity in healthy individuals and patients with OD of diff ...

2025

Direct Measurement of Effective Diffusion Coefficients in Nanochannels Using Steady-State Dispersion Effects

Philippe Renaud, Arnaud Bertsch, Nicolas Durand

We present a method to measure effective diffusion coefficients of fluorescently labeled molecules inside a nanofluidic system. Molecules with small diffusion coefficients show a larger lateral dispersion than highly diffusive species, which is counterintu ...

American Institute of Physics2007