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Matthias Lütolf

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Related publications (180)

Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

Matthias Lütolf, Michaël Unser, Nathalie Brandenberg, Thanh-An Michel Pham, Fangshu Yang

Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the comput ...

2021

3D extrusion bioprinting

Matthias Lütolf, Tania Hübscher

Three-dimensional (3D) bioprinting strategies use computer-aided processes to enable automated simultaneous spatial patterning of cells and/or biomaterials. These technologies are suitable for a broad range of biomedical applications owing to their capabil ...

SPRINGERNATURE2021

Capturing Cardiogenesis in Gastruloids

Matthias Lütolf, Romain Guiet, Mehmet Ugur Girgin, Giuliana Rossi, Andrea Boni, Nicolas Antoine Vincent Broguiere

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

CELL PRESS2021

A functional genetic toolbox for human tissue-derived organoids

Matthias Lütolf, Saba Rezakhani

Human organoid systems recapitulate key features of organs offering platforms for modelling developmental biology and disease. Tissue-derived organoids have been widely used to study the impact of extrinsic niche factors on stem cells. However, they are ra ...

eLIFE SCIENCES PUBL LTD2021

Engineering organoids

Matthias Lütolf, Moritz Hofer

Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in cult ...

NATURE RESEARCH2021

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues

Matthias Lütolf, Mehmet Ugur Girgin, Nicolas Antoine Vincent Broguiere

When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and patterning along the three major body axes. However, these structures, called gastru ...

2021

Bioengineered embryoids mimic post-implantation development in vitro

Matthias Lütolf, Mehmet Ugur Girgin, Nicolas Antoine Vincent Broguiere

The difficulty of studying post-implantation development in mammals has sparked a flurry of activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent stem cells. Previous approaches to derive embryoids either lack the phys ...

Nature Portfolio2021

Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society)

Matthias Lütolf

CELL PRESS2021

Device for manipulating mammalian cells with high collection capability

Matthias Lütolf, Nathalie Brandenberg, Sylke Höhnel

2021

3D-printable plastics compatible with CAR T-cell production

Matthias Lütolf

ELSEVIER2021

Bioengineering in vitro models of embryonic development

Matthias Lütolf

Stem cell-based in vitro models of embryonic development have been established over the last decade. Such model systems recapitulate aspects of gametogenesis, early embryonic development, or organogenesis. They enable experimental approaches that have not ...

2021

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Matthias Lütolf, Mauro Delorenzi, Laureline Wetterwald, Sina Nassiri, Michele De Palma, Mario Leonardo Squadrito, Nikolche Gjorevski, Alan Nicolas Thierry Guichard, Simone Ragusa, Borja Prat Luri

Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential respon ...

2020

Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures

Matthias Lütolf, Nathalie Brandenberg

The development of improved methods to culture retinal organoids is relevant for the investigation of mechanisms of retinal development under pathophysiological conditions, for screening of neuroprotective compounds, and for providing a cellular source for ...

Nature Research2020

A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

Matthias Lütolf, Marlen Knobloch, Mergim Ramosaj, Sonja Giger

Fatty acid beta-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The endogenous metabolite malonyl-CoA modulates lipid metabol ...

2020

In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro

Matthias Lütolf, Aline Roch, Vincent Trachsel, Mukul Girotra

Hematopoietic stem cells (HSCs) are responsible for life-long production of all mature blood cells. Under homeostasis, HSCs in their native bone marrow niches are believed to undergo asymmetric cell divisions (ACDs), with one daughter cell maintaining HSC ...

2020

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Matthias Lütolf, Vincent Milleret, Aline Roch, Stéphanie Elisabeth Metzger, Philipp Sebastian Lienemann, Martin Ehrbar, Olaia Maria Naveiras Torres-Quiroga, Panagiota Papageorgiou, Queralt Vallmajó Martín, Manuel Koch

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...

WILEY2020

Polarised three-dimensional cellular aggregates

Matthias Lütolf, Giuliana Rossi

Polarised three-dimensional cellular aggregates (or gastruloids) generated in vitro from one or more pluripotent stem cells are provided. Methods for obtaining polarised three-dimensional cellular aggregates and cells (e.g. progenitor cells and derivatives ...

2020

Breaking the Barriers in Engineering Organoids and Tissues with Advanced Materials

Matthias Lütolf

2020

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal

Matthias Lütolf, Aline Roch

Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore how hematopoietic stem cell (HSC) divisions patt ...

CELL PRESS2020

Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Riccardo Rizzo

Three-dimensional (3D) control over the placement of bioactive cues is fundamental to understand cell guidance and develop engineered tissues. Two-photon patterning (2PP) provides such placement at micro- to millimeter scale, but nonspecific interactions b ...

Wiley-V C H Verlag Gmbh2020

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