Publications by Matthias Lütolf

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Highlights • Crypt-like geometry promotes maturation of fetal intestinal epithelial cells • Engineered tissues display multi-lineage differentiation and epithelial organization • Cell crowding reduces YAP1 activity to drive epithelial maturation • YAP activity modulates cell lineage specification in vivo

DisCo is a deterministic droplet microfluidics tool for single-cell analysis on low cell input samples, which is demonstrated to profile individual intestinal organoids and in vivo-derived small tissues. ...

The invention provides methods for producing arrays of organoids, the arrays thereof and uses of such arrays. ...

Intestinal organoids have become an important model system in basic and translational research, but their culture typically relies on an ill-defined laminin-rich extracellular matrix (ECM). Using tunable and chemically defined 3D hydrogels, we systematically explored the role of the ECM during murine and human intestinal organoid development. We discovered that without exogenous laminin, stem cells developed into intestinal epithelia with a large proportion of regenerative cells. This population secreted a

Matthias Lütolf

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Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition

Deterministic scRNA-seq captures variation in intestinal crypt and organoid composition

A Versatile Approach to Engineering Biomolecule-Presenting Cellular Microenvironments

Organoid arrays

A bioinspired synthetic niche enables culture of liver organoids suitable for clinical application

Deciphering extrinsic regulation of stem cell differentiation in 3D

An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation

Engineering synthetic stem cell niches

Cell Patterning Using Nanostencil Lithography: An Alternative to Micro-Contact Printing

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic‐Fluorescence Imaging (Small Methods 10/2025)

Artificial niches that direct stem cell fate

Bioengineering mini-colons for ex vivo colorectal cancer research