Publication

Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition

Matthias Lütolf
2026

Abstract

Highlights • Crypt-like geometry promotes maturation of fetal intestinal epithelial cells • Engineered tissues display multi-lineage differentiation and epithelial organization • Cell crowding reduces YAP1 activity to drive epithelial maturation • YAP activity modulates cell lineage specification in vivo

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