Publications by Horst Arthur Vogel

Related publications (115)

Investigating cellular signalling at the nanometer and attoliter scale

Spatial compartmentalisation is a prerequisite for the creation of living matter. Without the existence of clearly defined borders, differentiation and diversity at the cellular level would not be possible. Most scientific disciplines that deal with dissol ...

2005

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Horst Arthur Vogel, Yury Tsybin, Marc Moniatte, Adrian Schmid, Diego Chiappe, Enrico Condemi

Tissue transglutaminase (TGase) has been implicated in a number of cellular processes and disease states, where the enzymatic actions of TGase may serve in both, cell survival and apoptosis. To date, the precise functional properties of TGase in cell survi ...

American Society for Biochemistry and Molecular Biology2011

Determining a receptor-ligand interaction useful in e.g. drug screening involves repetitive application of reversibly binding fluorescent ligands with fast association-dissociation kinetics

Horst Arthur Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

NOVELTY - Determining a receptor-ligand interaction involves repeatedly contacting a cell comprising a receptor, with a ligand, of the receptor in which the ligand has a fluorescence labeling group and binds reversibly to the receptor under conditions in w ...

2006

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Arthur Vogel, Nicolas Mermod, Luigino Grasso, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

Observation of the rare B-s(0)->mu(+)mu(-) decay from the combined analysis of CMS and LHCb data

Jian Wang, Matthias Finger, Olivier Schneider, Qian Wang, Zhirui Xu, Yiming Li, João Miguel das Neves Duarte, Matthias Wolf, Varun Sharma, Yi Zhang, Lei Zhang, Tian Cheng, Yixing Chen, Alexis Kalogeropoulos, Ioannis Papadopoulos, Konstantin Androsov, Jan Steggemann, Aurelio Bay, Ekaterina Kuznetsova, Ho Ling Li, Guido Haefeli, Jessica Prisciandaro, Tatsuya Nakada, Christoph Frei, Mark Tobin, Frédéric Blanc, Minh Tâm Tran, Michel De Cian, Greig Alan Cowan, Maurizio Martinelli, Donal Patrick Hill, Roberto Castello, Liang Sun, Lesya Shchutska, Pietro Marino, Luca Pescatore, Mirco Dorigo, Jean Wicht, Sebastiana Gianì, Liupan An, Elena Graverini, Federico Leo Redi, Chitsanu Khurewathanakul, Ilya Komarov, Bastien Luca Muster, Frédéric Guillaume Dupertuis, Horst Arthur Vogel, Wei Sun, Julien Rouvinet, Pierre Jaton, Barinjaka Rakotomiaramanana, Alessandro Mapelli, Doohyun Kim, Martin George Friedl, Joo Yeon Kim

The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilitie ...

Nature Publishing Group2015

Recombinant expression and functional characterization of the mouse olfactory receptor mOR256-17 in mammalian cells

Horst Arthur Vogel, Horst Pick, Luigino Grasso, Thamani Dahoun

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system in recognizing and discriminating a nearly unlimited number of structurally diverse odorous molecules. The mol ...

2011

Dual activities of odorants on olfactory and nuclear hormone receptors

Horst Arthur Vogel, Horst Pick, Olivia Baud, Sylvain Etter

We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neurons and the human nuclear estrogen rec ...

American Society for Biochemistry and Molecular Biology2009

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Horst Arthur Vogel, Horst Pick, Shuguang Yuan, Thamani Dahoun, Marc Brugarolas Campillos

The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of most ORs have not yet been identified and potential non-olfactory processes m ...

Springer2019

Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Horst Arthur Vogel, Shuguang Yuan

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the nervous system. They have been shown to be modulated by the lipid environment, however the underlying mechanism is not ...

Nature Research2021

Enhancing the Signaling of GPCRs via Orthosteric Ions

Horst Arthur Vogel, Shuguang Yuan

G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

AMER CHEMICAL SOC2020

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

Horst Arthur Vogel, Kai Johnsson, Rudolf Hovius, Jean-Manuel Segura, Nathalie George

The lateral organization of a prototypical G protein-coupled receptor, the neurokinin-1 receptor (NK1R), was investigated in living cells by fluorescence resonance energy transfer (FRET) microscopy, taking advantage of the recently developed acyl carrier p ...

National Academy of Sciences2006

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS

Horst Arthur Vogel, Rudolf Hovius, Jean-Manuel Segura, Joachim Piguet, Christoph Schreiter

Nicotinic acetylcholine receptors (nAChR) in muscle fibers are densely packed in the postsynaptic region at the neuromuscular junction. Rapsyn plays a central role in directing and clustering nAChR during cellular differentiation and neuromuscular junction ...

American Society for Biochemistry and Molecular Biology2011

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Horst Arthur Vogel, Shuguang Yuan

Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, ...

Nature Publishing Group2014

Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps

Horst Arthur Vogel, Henning Paul-Julius Stahlberg, Cédric Deluz, Ghérici Hassaïne, Menno Berend Tol

Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...

Amer Soc Biochemistry Molecular Biology Inc2013

Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel

Horst Arthur Vogel, Menno Berend Tol

Multimeric membrane proteins are produced in the endoplasmic reticulum and transported to their target membranes which, for ion channels, is typically the plasma membrane. Despite the availability of many fully assembled channel structures, our understandi ...

SPRINGERNATURE2024

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Horst Arthur Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

Membrane nanotubes drawn by optical tweezers transmit electrical signals between mammalian cells over long distances

Horst Arthur Vogel, Marinela Gjoni Boillat, Davor Kosanic

Biological cells continuously change shape allowing essential functions such as cell motility, vesicle-mediated release/uptake of soluble and membrane components or nanotube-mediated cell–cell communications. Here we use single cell micromanipulation to in ...

Royal Society of Chemistry2010

Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays

Giovanni De Micheli, Yusuf Leblebici, Horst Arthur Vogel, Luca Benini, Carlotta Guiducci, Yüksel Temiz, Samuel Terrettaz

This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flex ...

2008

The Mechanism of Ligand-Induced Activation or Inhibition of - and -Opioid Receptors

Horst Arthur Vogel, Shuguang Yuan

G-protein-coupled receptors (GPCRs) are important targets for treating severe diseases. However why certain molecules act as activators whereas others, with similar structures, block GPCR activation, is poorly understood since the same molecule can activat ...

Wiley-Blackwell2015

Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42

Horst Arthur Vogel

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific inhibitor of ClC- ...

Nature Portfolio2023