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Nikolaos Stergiopoulos

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Related publications (238)

Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye

Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. The cannabinoid system might regulate peripheral mechanisms of sexual function; ...

Hindawi Publishing Corporation2013

Spatio-Temporal Regularization Of Flow-Fields

Nikolaos Stergiopoulos, Michaël Unser, Pouya Dehghani Tafti, Emrah Bostan, Orestis Vardoulis, Davide Piccini

We introduce a novel variational framework for the regularized reconstruction of time-resolved volumetric flow fields. Our objective functional takes the physical characteristics of the underlying flow into account in both the spatial and the temporal doma ...

IEEE2013

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva

Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...

Wiley-Blackwell2013

Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice

Nikolaos Stergiopoulos, Luciano Dos Santos Aggum Capettini, Danielle Gomes Passos Silva, Jean-Christophe Copin, Katia Galan

Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of the CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactiv ...

Nature Publishing Group2013

Effects of Isoflurane Anesthesia on Aortic Compliance and Systemic Hemodynamics in Compliant and Noncompliant Aortas

Nikolaos Stergiopoulos

Objectives: To investigate the effect of general anesthesia on aortic compliance and other cardiovascular hemodynamics in chronically instrumented pigs with compliant and noncompliant (stiff) aortas. Design: Experimental study. Setting: University animal l ...

W B Saunders Co-Elsevier Inc2013

Physiological simulation of blood flow in the aorta: comparison of hemodynamic indices as predicted by 3-D FSI, 3-D rigid wall and 1-D models

Nikolaos Stergiopoulos, Alfio Quarteroni, Simone Deparis, Philippe Reymond, Paolo Crosetto

Interest in patient-specific blood-flow circulation modeling has increased substantially in recent years. The availability of clinical data for geometric and elastic properties together with efficient numerical methods has now made model rendering feasible ...

Elsevier2013

The selective pharmacologic inhibition of CXC chemokines is associated with an improvement of histological features of vulnerability in mouse atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Wiley-Blackwell2013

Pathophysiological role of the renin-angiotensin system on erectile dysfunction

Nikolaos Stergiopoulos

Background The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionall ...

Wiley-Blackwell2013

ACE2 Activation Protects Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Lippincott Williams & Wilkins2013

Validation of a novel and existing algorithms for the estimation of pulse transit time: advancing the accuracy in pulse wave velocity measurement

Nikolaos Stergiopoulos, Orestis Vardoulis

The method used for pulse transit time (PTT) estimation critically affects the accuracy and precision of regional pulse wave velocity (PWV) measurements. Several methods of PTT estimation exist, often yielding substantially different PWV values. Since ther ...

Amer Physiological Soc2013

Arterial stiffness of the internal carotid artery does not distinguish patients with stable unruptured aneurysms from normal controls

Nikolaos Stergiopoulos, Philippe Reymond, Daniel Ruefenacht, Edouard Fonck

Karger2013

Role of the renin-angiotensin system on abdominal aortic aneurysms

Nikolaos Stergiopoulos, Bram Trachet

BackgroundAbdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharm ...

Wiley-Blackwell2013

Brachial artery waveforms for automatic blood pressure measurement

Nikolaos Stergiopoulos

Theoretically the auscultatory method using Korotkoff sounds is more related to the maximum artery closure status, while the oscillometric method is more related to the overall artery closure status under the cuff. Therefore, the latter is less accurate th ...

Elsevier2013

Arterial stiffness of the internal carotid artery does not distinguish patients with stable unruptured aneurysms from normal controls

Nikolaos Stergiopoulos, Philippe Reymond, Daniel Ruefenacht, Edouard Fonck

Karger2013

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers

Nikolaos Stergiopoulos, Bryn Andrew Martin

Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no wid ...

Springer-Verlag2013

Active axial stress in mouse aorta

Alexander Rachev, Nikolaos Stergiopoulos, Aristotelis Agianniotis

The study verifies the development of active axial stress in the wall of mouse aorta over a range of physiological loads when the smooth muscle cells are stimulated to contract. The results obtained show that the active axial stress is virtually independen ...

Elsevier2012

Ambulatory arterial stiffness index does not accurately assess arterial stiffness

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers

Introduction: The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure monitoring (ABPM) recordings, has been proposed as a surrogate marker of arterial stiffness. However, there is controversy to what extent it reflects stiff ...

Lippincott, Williams & Wilkins2012

A method for the quantification of the pressure dependent 3D collagen configuration in the arterial adventitia

Nikolaos Stergiopoulos, Jelle Tymen Christiaan Schrauwen

Collagen plays an important role in the response of the arterial wall to mechanical loading and presumably has a load-bearing function preventing overdistension. Collagen configuration is important for understanding this role, in particular in mathematical ...

Elsevier2012

3D simulation of the aqueous flow in the human eye

Nikolaos Stergiopoulos, Philippe Reymond, Sylvain Roy, Adan Villamarin, Reda Hasballa, Orestis Vardoulis

Glaucoma results in an increase in the resistance of the aqueous humor outflow, which in turn leads to an increase of the intraocular pressure (IOP). Several treatments are proposed to reduce and stabilize the IOP that include medications, filtering surger ...

Elsevier Sci Ltd2012

Generic and patient-specific models of the arterial tree

Nikolaos Stergiopoulos, Philippe Reymond, Orestis Vardoulis

Recent advance in imaging modalities used frequently in clinical routine can provide description of the geometrical and hemodynamical properties of the arterial tree in great detail. The combination of such information with models of blood flow of the arte ...

Springer Netherlands2012

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