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Nikolaos Stergiopoulos

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Related publications (238)

A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system

Nikolaos Stergiopoulos, Philippe Reymond, Bryn Andrew Martin

Martin BA, Reymond P, Novy J, Baledent O, Stergiopulos N. A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. Am J Physiol Heart Circ Physiol 302: H1492-H1509, 2012. First published January 20, 2012; doi: 10.1152/ajpheart.006 ...

2012

Patient-specific mean pressure drop in the systemic arterial tree, a comparison between 1-D and 3-D models

Nikolaos Stergiopoulos, Philippe Reymond, François Lazeyras

One-dimensional models of the systemic arterial tree are useful tools for studying wave propagation phenomena, however, their formulation for frictional losses is approximate and often based on solutions for developed flow in straight non-tapered arterial ...

Elsevier2012

Apparatus and methods for treating excess intraocular fluid

Nikolaos Stergiopoulos, Stéphane Bigler

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit. The implantable device includes a non-invasively adju ...

2012

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Nikolaos Stergiopoulos, Michaël Unser, Daniel Sage, Alessandra Griffa, Aristotelis Agianniotis, Jelle Tymen Christiaan Schrauwen

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis

Nikolaos Stergiopoulos, Orestis Vardoulis

Papaioannou TG, Vardoulis O, Stergiopulos N. The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis. Am J Physiol Heart Circ Physiol 302: H2064-H2073, 2012. First published March 16, 2012; doi: ...

2012

Response to comments regarding Vardoulis O, et al., Impact of Aortic Grafts on Arterial Pressure: A Computational Fluid Dynamics Study. Eur J Vasc Endovasc Surg 2011;42:704-10

Nikolaos Stergiopoulos, Philippe Reymond, Bryn Andrew Martin, Orestis Vardoulis, Eline Coppens

Elsevier2012

On the Estimation of Total Arterial Compliance from Aortic Pulse Wave Velocity

Nikolaos Stergiopoulos, Orestis Vardoulis

Total arterial compliance (C (T)) is a main determinant of cardiac afterload, left ventricular function and arterio-ventricular coupling. C (T) is physiologically more relevant than regional aortic stiffness. However, direct, in vivo, non-invasive, measure ...

Springer US2012

Bioengineering and Clinical Perspectives in Diagnostic and Therapeutic Applications of Microbubbles

Nikolaos Stergiopoulos

Bentham Science Publishers2012

Systolic Hypertension Mechanisms: Effect of Global and Local Proximal Aorta Stiffening on Pulse Pressure

Nikolaos Stergiopoulos, Nico Westerhof, Philippe Reymond

Decrease in arterial compliance leads to an increased pulse pressure, as explained by the Windkessel effect. Pressure waveform is the sum of a forward running and a backward running or reflected pressure wave. When the arterial system stiffens, as a result ...

Springer US2012

Wall properties of the apolipoprotein E-deficient mouse aorta

Nikolaos Stergiopoulos, Aristotelis Agianniotis

Objectives: We quantified the dysfunction of the aortic wall, determined structural and elastic properties, and provided histological data of the thoracic aortas of apolipoprotein E (apoE)-deficient mice which are used as model of atherosclerosis. Methods: ...

Elsevier Ireland Ltd2012

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Nikolaos Stergiopoulos, Danielle Gomes Passos Silva

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidi ...

Schattauer Gmbh-Verlag Medizin Naturwissenschaften2012

Time course of flow-induced adaptation of carotid artery biomechanical properties, structure and zero-stress state in the arteriovenous shunt

Nikolaos Stergiopoulos

Numerous studies have provided evidence of diameter adaptation secondary to flow-overload. but with ambiguous findings vis a vis other morphological parameters and information on the biomechanical aspects of arterial adaptation is rather incomplete. We exa ...

2012

Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine

Nikolaos Stergiopoulos, Bryn Andrew Martin

Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three direct ...

Public Library Science2012

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacologi ...

Oxford University Press2012

Treatment with chemokine-binding protein Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke in mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Academic Press Ltd- Elsevier Science Ltd2012

Validation of the Arteriograph working principle: questions still remain

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

Lippincott, Williams & Wilkins2011

Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms

Nikolaos Stergiopoulos, Luca Augsburger, Philippe Reymond

Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, ...

Springer US2011

Impact of Aortic Grafts on Arterial Pressure: A Computational Fluid Dynamics Study

Nikolaos Stergiopoulos, Philippe Reymond, Bryn Andrew Martin, Orestis Vardoulis, Eline Coppens

Objective: Vascular prostheses currently used in vascular surgery do not have the same mechanical properties as human arteries. This computational study analyses the mechanisms by which grafts, placed in the ascending aorta (proximal) and descending aorta ...

Elsevier2011

Role of elastin anisotropy in structural strain energy functions of arterial tissue

Nikolaos Stergiopoulos, Edouard Fonck

The vascular wall exhibits nonlinear anisotropic mechanical properties. The identification of a strain energy function (SEF) is the preferred method to describe its complex nonlinear elastic properties. Earlier constituent-based SEF models, where elastin i ...

Springer-Verlag2011

Validation of a patient-specific one-dimensional model of the systemic arterial tree

Nikolaos Stergiopoulos, Philippe Reymond, Yvette Bohraus, François Lazeyras

Reymond P, Bohraus Y, Perren F, Lazeyras F, Stergiopulos N. Validation of a patient-specific one-dimensional model of the systemic arterial tree. Am J Physiol Heart Circ Physiol 301: H1173-H1182, 2011. First published May 27, 2011; doi:10.1152/ajpheart.008 ...

2011

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