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Nikolaos Stergiopoulos

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Related publications (238)

Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation

Nikolaos Stergiopoulos, Patrick Segers, Jessica Sordet, Alessandra Piersigilli, Bram Trachet, Peter Modregger

Aims In this work, we provide novel insight into the morphology of dissecting abdominal aortic aneurysms in angiotensin II-infused mice. We demonstrate why they exhibit a large variation in shape and, unlike their human counterparts, are located suprarenal ...

Oxford University Press2015

Quantification of focal lacerations in the tunica media that cause ascending aortic aneurysm in angiotensin II-infused mice

Nikolaos Stergiopoulos, Patrick Segers, Alessandra Piersigilli, Bram Trachet, Lydia Aslanidou

Oxford Univ Press2015

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet

Aims While angiotensin II-infused mice are the most popular model for preclinical aneurysm research, representative data on incidence, severity, and mortality of dissecting abdominal aortic aneurysms (AAAs) have never been established, and the influence of ...

Oxford University Press2015

In vivo evaluation of a novel 'diastole-patching' algorithm for the estimation of pulse transit time: advancing the precision in pulse wave velocity measurement

Nikolaos Stergiopoulos, Orestis Vardoulis

Carotid-to-femoral pulse wave velocity (PWV) is the gold standard for the assessment of aortic stiffness. It is calculated by the ratio of pulse transit time (PTT) between two arterial sites and the distance between them. The precision of PTT estimation de ...

Institute of Physics2015

Improved Variational Denoising of Flow Fields with Application to Phase-Contrast MRI Data

Nikolaos Stergiopoulos, Michaël Unser, Emrah Bostan, Orestis Vardoulis, Stamatios Lefkimmiatis

We propose a new variational framework for the problem of reconstructing flow fields from noisy measurements. The formalism is based on regularizers penalizing the singular values of the Jacobian of the field. Specifically, we rely on the nuclear norm. Our ...

IEEE Institute of Electrical and Electronics Engineers2015

Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice

Nikolaos Stergiopoulos

Experimental data from animal models and clinical studies support connections between the haemostasis and inflammation in atherogenesis. These interfaces among inflammation and thrombogenesis have been suggested as targets for pharmacological intervention ...

Elsevier Science Inc2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Maiia Bragina

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

A New Adjustable Glaucoma Drainage Device

Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. This work is focused on the testing of a new experimental noninvasively adjustable glaucoma drainage device (AGDD) that allows for the control of its outflow resistance to modulate intraocular pressure (IOP) in a customized fashion. METHODS. Six A ...

Association for Research in Vision and Ophthalmology2014

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output

Nikolaos Stergiopoulos, Orestis Vardoulis

Surgical or critically ill patients often require continuous assessment of cardiac output (CO) for diagnostic purposes or for guiding therapeutic interventions. A new method of non-invasive CO estimation has been recently developed, which is based on press ...

Elsevier2014

The Role of the Renin-Angiotensin System in Erectile Dysfunction: Present and Future

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system. Furthermore, clear compelling evidence indicates that this system is an essential modulator of penile erectile. Higher levels of angiotensin (Ang) II, the main component of ...

Springer International Publishing2014

In Vivo Testing of a Novel Adjustable Glaucoma Drainage Device

André Mermoud, Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. We report on the in vivo testing of a novel noninvasively adjustable glaucoma drainage device (AGDD), which features an adjustable outflow resistance, and assess the safety and efficiency of this implant. METHODS. Under general anesthesia, the AGD ...

Association for Research in Vision and Ophthalmology2014

Ace2 Is Expressed In The Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemic-Induced Injures

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Total arterial compliance estimated by a novel method and all-cause mortality in the elderly: the PROTEGER study

Nikolaos Stergiopoulos, Orestis Vardoulis

Aortic stiffness, assessed by carotid-to-femoral pulse wave velocity (PWV), often fails to predict cardiovascular (CV) risk and mortality in the very elderly. This may be due to the non-linear association between PWV and compliance or to blood pressure dec ...

Springer Verlag2014

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionHypercholesterolemia is a prevalent risk factor for the development of erectile dysfunction (ED), mostly due to an increase in oxidative stress and impaired nitric oxide (NO) bioavailability within the penis. Arginase is an enzyme that shares t ...

Wiley-Blackwell2014

Angiotensin-Converting Enzyme 2 Is Expressed In Corpus Cavernosum And Produces Beneficial Effects Against Hypercholesterolemia-Induced Injuries

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Arginase Inhibition Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Impairment

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

Wiley-Blackwell2014

Validation of Algorithms for the Estimation of Pulse Transit Time: Where do We Stand Today?

Nikolaos Stergiopoulos, Orestis Vardoulis

Springer Verlag2014

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