Henning Paul-Julius Stahlberg

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In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many ways, enabling the diseases to be classified according to fibril structure. ...

Urease converts urea into ammonia and carbon dioxide and makes urea available as a nitrogen source for all forms of life except animals. In human bacterial pathogens, ureases also aid in the invasion of acidic environments such as the stomach by raising th ...

Short prokaryotic argonaute (pAgo) and toll/interleukin-1 receptor/resistance protein (TIR)-analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its prokaryotic host through an abortive infection mechanism. Monomeric SPARTA se ...

Cryo-electron microscopy with energy resolution, using the EELS-STEM method, allows researchers to identify the approximate locations of certain heavier atoms within single frozen, hydrated protein particles. ...

Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole biogenesis has been well documented, its native architecture ...

The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...

gamma-Secretase is a multi-subunit membrane protease complex that catalyses the final intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of amyloid-beta peptides (A beta), which are implicated as the causative ...

How cellular organelles assemble is a fundamental question in biology. The centriole organelle organizes around a nine-foldsymmetrical cartwheel structure typically 100 nm high comprising a stack of rings that each accommodates nine homodimers of SAS-6 pro ...

The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeats (TPR) fused with a CHAT domain). The Craspase ...

Organohalide-respiring bacteria are key organisms for the bioremediation of soils and aquifers contaminated with halogenated organic compounds. The major players in this process are respiratory reductive dehalogenases, corrinoid enzymes that use organohali ...

CryoEM Dataset of SARS-CoV-2 S Omicron Spike B.1.1.529

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.2.12.1 Spike

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.1 Spike

Henning Paul-Julius Stahlberg

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Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog (vol 5, 355, 2022)

Structural strains of misfolded tau protein define different diseases

High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica

Activation mechanism of a short argonaute-TIR prokaryotic immune system

Cryo-electron microscopy in color

Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography

Cryo-EM structure of native human thyroglobulin

Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson’s Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography

The lipidome associated with the gamma-secretase complex is required for its integrity and activity

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

Structural insights into the regulation of Cas7-11 by TPR-CHAT

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

Phase Contrast 4D-STEM Tomography of Thick Biological Specimens

Single Particle Analysis for High-Resolution 2D Electron Crystallography

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

SARS-CoV-2 S Omicron Spike B.1.1.529

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.2.12.1 Spike

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.1 Spike

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies