Henning Paul-Julius Stahlberg

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (71)

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

Henning Paul-Julius Stahlberg, Pierre Gönczy, Mircea Ioan Iacovache, Virginie Hamel, Isabelle Fluckiger, Paul Guichard, Veronika Nemcíková Villímová, Niccolo Banterle

How cellular organelles assemble is a fundamental question in biology. The centriole organelle organizes around a nine-foldsymmetrical cartwheel structure typically 100 nm high comprising a stack of rings that each accommodates nine homodimers of SAS-6 pro ...

Springer Nature2017

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Henning Paul-Julius Stahlberg, Horst Vogel, Ghérici Hassaïne

The mouse serotonin 5-HT3A receptor is a homo-pentameric ligand-gated ion channel (pLGIC) mediating fast excitatory neurotransmission in the central nervous system. The molecular mechanism of ion permeation of 5-HT3A receptors triggered by the neurotransmi ...

Pergamon-Elsevier Science Ltd2017

The lipidome associated with the gamma-secretase complex is required for its integrity and activity

Henning Paul-Julius Stahlberg, Patrick Fraering, Hermeto Gerber, Guillermo Miguel Garcia Osuna

gamma-Secretase is a multi-subunit membrane protease complex that catalyses the final intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of amyloid-beta peptides (A beta), which are implicated as the causative ...

Portland Press Ltd2016

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Luigino Grasso, Ghérici Hassaïne

The function of membrane proteins is best understood if their structure in the lipid membrane is known. Here, we determined the structure of the mouse serotonin 5-HT3 receptor inserted in lipid bilayers to a resolution of 12 Å without stabilizing antibodie ...

Elsevier2016

Structure of the T4 baseplate and its function in triggering sheath contraction

Henning Paul-Julius Stahlberg, Petr Leiman, Christopher Browning, Ricardo Cesar Guerrero Ferreira, Nikolai Prokhorov

Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell membranes. This macromolecular machine resembles a stretched, coiled spri ...

Nature Publishing Group2016

X-ray structure of the mouse serotonin 5-HT3 receptor

Rudolf Hovius, Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Luigino Grasso, Romain Wyss, Menno Berend Tol, Ghérici Hassaïne

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly un ...

Nature Publishing Group2014

openBEB: open biological experiment browser for correlative measurements

Henning Paul-Julius Stahlberg, Sophie Roizard

Background: New experimental methods must be developed to study interaction networks in systems biology. To reduce biological noise, individual subjects, such as single cells, should be analyzed using high throughput approaches. The measurement of several ...

Biomed Central Ltd2014

In situ structural analysis of the Yersinia enterocolitica injectisome

Henning Paul-Julius Stahlberg, Matteo Thomas Degiacomi, Matteo Dal Peraro, Marco Stenta

Injectisomes are multi-protein transmembrane machines allowing pathogenic bacteria to inject effector proteins into eukaryotic host cells, a process called type III secretion. Here we present the first three-dimensional structure of Yersinia enterocolitica ...

Elife Sciences Publications Ltd2013

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Henning Paul-Julius Stahlberg, Matteo Thomas Degiacomi, Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Matteo Dal Peraro

Aerolysin is the founding member of a superfamily of (beta-pore-forming toxins whose pore structure is unknown. We have combined X-ray crystallography, cryo-EM, molecular dynamics and computational modeling to determine the structures of aerolysin mutants ...

Nature Publishing Group2013

Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps

Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Menno Berend Tol, Ghérici Hassaïne

Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...

Amer Soc Biochemistry Molecular Biology Inc2013

Transmission electron microscopy of transmembrane proteins

Henning Paul-Julius Stahlberg

EPFL1997

Page 4 sur 4