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This lecture explores the synergy between nanomaterial and CMOS electronics for (bio)sensing applications, focusing on the electromigration method for nanogap electrodes. The lecture covers topics such as the electromigration of metal atoms, the importance of gold probes, electrothermal modeling, and the electrothermal simulation performed by COMSOL. It also delves into the electrothermal model for nanogap fabrication, numerical atomic flux, and the system implemented for controlling experiments. The lecture concludes with discussions on lithography mask layout, chip bonding, and the application of electromigration models in nanoelectronics.