Lecture

Biosensors Fundamentals: Lab-on-Chip Systems

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In course

EE-515: Fundamentals of biosensors and electronic biochips

The labels "biosensor" and "eBiochip" have been employed to refer to the most diverse systems and in several fields of application. The course is meant not only to provide means to dig into this sea

Description

This lecture covers the fundamentals of biosensors and electronic biochips, including the analytical performance of biosensors, surface ligand binding biosensors, assay configurations, sensors performance in the presence of convection, binary diagnostic tests, solid-liquid interface phenomena, electrodes in lab-on-chip systems, field-effect devices for bioanalytics, and interfacing and packaging of biochips.

Instructor

Carlotta Guiducci

Teaching & PhD PhD Students Micaela Siria Cristofori, Edoardo Bargis, Yide Jiao, Seyyed Hamid Sadat Mansoury Past EPFL PhD Students Giulia Cappi, Enrico Accastelli, Anna Ferretti, Enrica Rollo, Samuel Kilchenmann, Elena-Diana Bojescu, Kevin Keim, Pierre-Emmanuel Marie Thiriet, Saurabh Tomar, Gloria Porro, Till Jonathan Ryser Past EPFL PhD Students as codirector Yüksel Temiz Courses Electrical systems and electronics I EE-295 The course has the aim to provide the fundamental knowledge and e

Official source

Related concepts (12)

Microfluidics

Microfluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.

Droplet-based microfluidics

Droplet-based microfluidics manipulate discrete volumes of fluids in immiscible phases with low Reynolds number and laminar flow regimes. Interest in droplet-based microfluidics systems has been growing substantially in past decades. Microdroplets offer the feasibility of handling miniature volumes (μl to fl) of fluids conveniently, provide better mixing, encapsulation, sorting, sensing and are suitable for high throughput experiments.

Lab-on-a-chip

A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids.

Paper-based microfluidics

Paper-based microfluidics are microfluidic devices that consist of a series of hydrophilic cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to a desired outlet or region of the device, by means of capillary action. This technology builds on the conventional lateral flow test which is capable of detecting many infectious agents and chemical contaminants. The main advantage of this is that it is largely a passively controlled device unlike more complex microfluidic devices.

Organ-on-a-chip

An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context.

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