Biomechanics in Organ-on-Chip Systems

This lecture explores the biomechanics of organ-on-chip systems, discussing the advantages, relevance of mechanobiology, and fabrication methods. It delves into the high surface-to-volume ratio, laminar flow, diffusion, less reagent consumption, safety, temperature control, high throughput, portability, and disposability. The lecture also covers single cell analysis, the development of organ-on-chip systems, and various fabrication methods like photolithography, soft lithography, and hot embossing. It highlights the importance of shear stress, diffusion, compression, stretching, micropatterning, substrate stiffness, and other mechanical stimuli in microsystems. The lecture concludes with insights into cell response and analysis techniques like Western blotting, PCR, and immunocytochemistry.