Lecture

Respiratory Regulation: Hemoglobin Dissociation Curve, CO Toxicity, and pH Control

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In course

BIO-377: Physiology by systems

Le but est de connaitre et comprendre le fonctionnement des systèmes cardiovasculaire, urinaire, respiratoire, digestif, ainsi que du métabolisme de base et sa régulation afin de déveloper une réflection scientifique biomédicale. ...

Description

This lecture covers the dissociation curve of hemoglobin in the lungs and tissues, the toxic role of CO in competing with O2 binding to hemoglobin, CO2 transport in the blood, the Haldane effect of O2 on CO2 saturation, ventilation regulation loops, O2 and CO2 chemical receptors, pH and CO2 role in respiration regulation, O2 level role in respiration regulation, hypoxic stimulus, hypoxia effect on exercise respiration response, EPO role in hypoxia control, blood pH regulation, effects of ventilation and chemical buffers on blood pH, and the impact of respiratory and metabolic disorders on pH.

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Instructor

Sylvain Roy

1995: Diplôme fédéral de médecin 2000: Thèse de doctorat en médecine 2001: Diplôme fédéral de spécialiste FMH en ophtalmologie et ophtalmochirurgie 2003: Diplôme d'étude spécialisée en ingénierie biomédicale

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Related concepts (32)

Acid–base homeostasis

Acid–base homeostasis is the homeostatic regulation of the pH of the body's extracellular fluid (ECF). The proper balance between the acids and bases (i.e. the pH) in the ECF is crucial for the normal physiology of the body—and for cellular metabolism. The pH of the intracellular fluid and the extracellular fluid need to be maintained at a constant level. The three dimensional structures of many extracellular proteins, such as the plasma proteins and membrane proteins of the body's cells, are very sensitive to the extracellular pH.

Buffer solution

A buffer solution (more precisely, pH buffer or hydrogen ion buffer) is an acid or a base aqueous solution consisting of a mixture of a weak acid and its conjugate base, or vice versa. Its pH changes very little when a small amount of strong acid or base is added to it. Buffer solutions are used as a means of keeping pH at a nearly constant value in a wide variety of chemical applications. In nature, there are many living systems that use buffering for pH regulation.

Blood

Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the circulatory system is also known as peripheral blood, and the blood cells it carries, peripheral blood cells. Blood is composed of blood cells suspended in blood plasma.

Blood smear

A blood smear, peripheral blood smear or blood film is a thin layer of blood smeared on a glass microscope slide and then stained in such a way as to allow the various blood cells to be examined microscopically. Blood smears are examined in the investigation of hematological (blood) disorders and are routinely employed to look for blood parasites, such as those of malaria and filariasis. A blood smear is made by placing a drop of blood on one end of a slide, and using a spreader slide to disperse the blood over the slide's length.

Blood test

A blood test is a laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick. Multiple tests for specific blood components, such as a glucose test or a cholesterol test, are often grouped together into one test panel called a blood panel or blood work. Blood tests are often used in health care to determine physiological and biochemical states, such as disease, mineral content, pharmaceutical drug effectiveness, and organ function.

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