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This lecture covers the fundamentals of neural signals and signal processing, focusing on the modeling and simulation of neural systems. Topics include the importance of modeling, types of models, neural structures, and the organization of the cortex. The lecture also delves into the classification of nerve fibers, neuron morphology, and the spinal cord's structure. Furthermore, it explores the generation of physiological signals, action potential propagation, and the use of hybrid models in neuroengineering.