Lecture

Randomized Trials and Simpson's Paradox

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In course

EE-209: Elements of statistics for data science

Théorie de l'estimation: estimateurs du maximum de vraisemblance, information de Fisher, inégalité de Cramer-Rao, intervalles de confiance. Tests d'hypothèses: cadre de Neyman-Pearson: test du rapport de vraisemblance, tests paramétriques et non-parmétriq ...

Description

This lecture discusses the importance of randomized clinical trials to avoid confounding variables and Simpson's paradox. It covers the concept of random assignment in clinical trials, ethical considerations, and the challenges of using observational data in various fields. The lecture also explains how to ensure treatment independence in trials and the implications of Simpson's paradox in data analysis.

Instructor

Florent Gérard Krzakala

Official source

Ontological neighbourhood

Statistics

Data collection: Experiment

Related concepts (32)

Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought.

Confounding

In causal inference, a confounder (also confounding variable, confounding factor, extraneous determinant or lurking variable) is a variable that influences both the dependent variable and independent variable, causing a spurious association. Confounding is a causal concept, and as such, cannot be described in terms of correlations or associations. The existence of confounders is an important quantitative explanation why correlation does not imply causation.

Ethics

Ethics or moral philosophy is a branch of philosophy that "involves systematizing, defending, and recommending concepts of right and wrong behavior". The field of ethics, along with aesthetics, concerns matters of value; these fields comprise the branch of philosophy called axiology. Ethics seeks to resolve questions of human morality by defining concepts such as good and evil, right and wrong, virtue and vice, justice and crime. As a field of intellectual inquiry, moral philosophy is related to the fields of moral psychology, descriptive ethics, and value theory.

Consolidated Standards of Reporting Trials

Consolidated Standards of Reporting Trials (CONSORT) encompasses various initiatives developed by the CONSORT Group to alleviate the problems arising from inadequate reporting of randomized controlled trials. It is part of the larger EQUATOR Network initiative to enhance the transparency and accuracy of reporting in research. The main product of the CONSORT Group is the CONSORT Statement, which is an evidence-based, minimum set of recommendations for reporting randomized trials.

Placebo-controlled study

Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham "placebo" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further "natural history" group that does not receive any treatment at all.

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