Lecture

Observational Studies: Pitfalls and Solutions

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CS-401: Applied data analysis

This course teaches the basic techniques, methodologies, and practical skills required to draw meaningful insights from a variety of data, with the help of the most acclaimed software tools in the data science world (pandas, scikit-learn, Spark, etc.) ...

Description

This lecture discusses the difference between experimental and observational studies, highlighting the pitfalls of the latter. It covers the challenges of drawing valid conclusions from 'found data' and motivates reading key books. The instructor uses Dr. Bob's smoking cure as a case study to explain the importance of randomization in experiments and the limitations of observational studies. The lecture introduces the concept of propensity scores to address the issue of unobserved covariates and emphasizes the need for sensitivity analysis to ensure the validity of conclusions. Various examples, including the smoking and lung cancer case, illustrate the application of these methods in real-world scenarios.

Instructors (2)

Maria Brbic

Maria Brbic is an assistant professor in computer science at EPFL. Prior to joining EPFL, Maria was a postdoctoral researcher in Computer Science at Stanford University working with Jure Leskovec. She received her PhD degree from University of Zagreb in 2019, while also researching at Stanford University and University of Tokyo. Her research was awarded with the Fulbright Scholarship, L’Oreal UNESCO for Women in Science Scholarship, Branimir Jernej award for outstanding publication in biology and biomedicine, and Josip Loncar Silver Plaque award for the best doctoral dissertation. She has been named a Rising Star in EECS by MIT in 2021. Her research is focused on developing new machine learning methods and applying her methods to advance biomedical research.

Robert West

Robert West is a tenure-track assistant professor of computer science at EPFL, where he heads the Data Science Lab. In his research, he develops and applies techniques in machine learning, computational social science, natural language processing, social network analysis, and data mining. Bob also collaborates closely with the Wikimedia Foundation, in his role as a Wikimedia Research Fellow. Bob’s work has won several awards, including best/outstanding paper awards at ICWSM’21, ICWSM’19, and WWW’13, a best-paper runner-up award at WWW’16, a Google Faculty Research Award, a Facebook Research Award, a Hewlett-Packard Graduate Fellowship, and a Facebook Graduate Fellowship. He is actively involved in the research community, e.g., as an Associate Editor of ICWSM and EPJ Data Science and as a co-founder of the Wiki Workshop (held at WWW and ICWSM) and the Applied Machine Learning Days. Bob received his PhD in Computer Science from Stanford University, his MSc from McGill University, Canada, and his undergraduate degree from Technische Universität München, Germany.[Last updated: 25 Aug 2021]

Official source

Ontological neighbourhood

Statistics

Data collection: Experiment

Related concepts (32)

Experiment

An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies.

Natural experiment

A natural experiment is a study in which individuals (or clusters of individuals) are exposed to the experimental and control conditions that are determined by nature or by other factors outside the control of the investigators. The process governing the exposures arguably resembles random assignment. Thus, natural experiments are observational studies and are not controlled in the traditional sense of a randomized experiment (an intervention study).

Design of experiments

The design of experiments (DOE or DOX), also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.

Quasi-experiment

A quasi-experiment is an empirical interventional study used to estimate the causal impact of an intervention on target population without random assignment. Quasi-experimental research shares similarities with the traditional experimental design or randomized controlled trial, but it specifically lacks the element of random assignment to treatment or control. Instead, quasi-experimental designs typically allow the researcher to control the assignment to the treatment condition, but using some criterion other than random assignment (e.

Randomized experiment

In science, randomized experiments are the experiments that allow the greatest reliability and validity of statistical estimates of treatment effects. Randomization-based inference is especially important in experimental design and in survey sampling. In the statistical theory of design of experiments, randomization involves randomly allocating the experimental units across the treatment groups. For example, if an experiment compares a new drug against a standard drug, then the patients should be allocated to either the new drug or to the standard drug control using randomization.

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